About WD repeat domain phosphoinositide-interacting protein 4
WD repeat domain phosphoinositide-interacting protein 4 (WDR45) is a protein
from Homo sapiens identified by UniProt accession
Q9Y484, 360 residues long.
MolForge cross-references it against 0 known binders and
115 disease associations.
Target properties
| Protein name | WD repeat domain phosphoinositide-interacting protein 4 |
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| UniProt accession | Q9Y484 |
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| Gene | WDR45 |
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| Organism | Homo sapiens |
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| Length | 360 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (115)
Diseases linked to this target (Open Targets).
- neurodegeneration with brain iron accumulation 5 · score 0.79
- Dystonia · score 0.61
- genetic disorder · score 0.54
- neurodegenerative disease · score 0.53
- Global developmental delay · score 0.48
- Intellectual disability · score 0.47
- X-linked cerebral-cerebellar-coloboma syndrome syndrome · score 0.44
- Seizure · score 0.41
- neurodegeneration with brain iron accumulation · score 0.37
- oculocutaneous albinism type 7 · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y484-F1 | alphafold | PREDICTED | 90.48 | — |
Amino-acid sequence (360 residues)
MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS MGLVEMLHRS NLLALVGGGS SPKFSEISVL IWDDAREGKD SKEKLVLEFT FTKPVLSVRM RHDKIVIVLK NRIYVYSFPD NPRKLFEFDT RDNPKGLCDL CPSLEKQLLV FPGHKCGSLQ LVDLASTKPG TSSAPFTINA HQSDIACVSL NQPGTVVASA SQKGTLIRLF DTQSKEKLVE LRRGTDPATL YCINFSHDSS FLCASSDKGT VHIFALKDTR LNRRSALARV GKVGPMIGQY VDSQWSLASF TVPAESACIC AFGRNTSKNV NSVIAICVDG TFHKYVFTPD GNCNREAFDV YLDICDDDDF
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