About V-type proton ATPase 116 kDa subunit a 2
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y487, 856 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | V-type proton ATPase 116 kDa subunit a 2 |
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| UniProt accession | Q9Y487 |
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| Gene | ATP6V0A2 |
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| Organism | Homo sapiens |
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| Length | 856 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- wrinkly skin syndrome · score 0.76
- autosomal recessive cutis laxa type 2A · score 0.75
- ALG9-congenital disorder of glycosylation · score 0.55
- cutis laxa · score 0.44
- autosomal recessive cutis laxa type 2, classic type · score 0.37
- genetic disorder · score 0.34
- Alpha-1-antitrypsin deficiency · score 0.34
- FEV/FVC ratio · score 0.26
- adiponectin measurement · score 0.22
- breast adenocarcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y487-F1 | alphafold | PREDICTED | 81.59 | — |
Amino-acid sequence (856 residues)
MGSLFRSETM CLAQLFLQSG TAYECLSALG EKGLVQFRDL NQNVSSFQRK FVGEVKRCEE LERILVYLVQ EINRADIPLP EGEASPPAPP LKQVLEMQEQ LQKLEVELRE VTKNKEKLRK NLLELIEYTH MLRVTKTFVK RNVEFEPTYE EFPSLESDSL LDYSCMQRLG AKLGFVSGLI NQGKVEAFEK MLWRVCKGYT IVSYAELDES LEDPETGEVI KWYVFLISFW GEQIGHKVKK ICDCYHCHVY PYPNTAEERR EIQEGLNTRI QDLYTVLHKT EDYLRQVLCK AAESVYSRVI QVKKMKAIYH MLNMCSFDVT NKCLIAEVWC PEADLQDLRR ALEEGSRESG ATIPSFMNII PTKETPPTRI RTNKFTEGFQ NIVDAYGVGS YREVNPALFT IITFPFLFAV MFGDFGHGFV MFLFALLLVL NENHPRLNQS QEIMRMFFNG RYILLLMGLF SVYTGLIYND CFSKSVNLFG SGWNVSAMYS SSHPPAEHKK MVLWNDSVVR HNSILQLDPS IPGVFRGPYP LGIDPIWNLA TNRLTFLNSF KMKMSVILGI IHMTFGVILG IFNHLHFRKK FNIYLVSIPE LLFMLCIFGY LIFMIFYKWL VFSAETSRVA PSILIEFINM FLFPASKTSG LYTGQEYVQR VLLVVTALSV PVLFLGKPLF LLWLHNGRSC FGVNRSGYTL IRKDSEEEVS LLGSQDIEEG NHQVEDGCRE MACEEFNFGE ILMTQVIHSI EYCLGCISNT ASYLRLWALS LAHAQLSDVL WAMLMRVGLR VDTTYGVLLL LPVIALFAVL TIFILLIMEG LSAFLHAIRL HWVEFQNKFY VGAGTKFVPF SFSLLSSKFN NDDSVA
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