About Meiosis regulator and mRNA stability factor 1
Meiosis regulator and mRNA stability factor 1 (MARF1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y4F3, 1742 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Meiosis regulator and mRNA stability factor 1 |
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| UniProt accession | Q9Y4F3 |
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| Gene | MARF1 |
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| Organism | Homo sapiens |
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| Length | 1742 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- Female infertility due to fertilization defect · score 0.11
- mean platelet volume · score 0.11
- Rare genetic female infertility · score 0.10
- oocyte maturation defect 11 · score 0.10
- female infertility due to zona pellucida defect · score 0.10
- female infertility due to oocyte meiotic arrest · score 0.10
- PR interval · score 0.09
- Hydatidiform Mole · score 0.09
- oocyte/zygote/embryo maturation arrest 17 · score 0.08
- premature ovarian failure 19 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y4F3-F1 | alphafold | PREDICTED | 62.08 | — |
Amino-acid sequence (1742 residues)
MMEGNGTENS CSRTRGWLQQ DNDAKPWLWK FSNCFSRPEQ TLPHSPQTKE YMENKKVAVE LKDVPSPLHA GSKLFPAVPL PDIRSLQQPK IQLSSVPKVS CCAHCPNEPS TSPMRFGGGG GGSGGTSSLI HPGALLDSQS TRTITCQVGS GFAFQSASSL QNASARNNLA GIASDFPSMC LESNLSSCKH LPCCGKLHFQ SCHGNVHKLH QFPSLQGCTS AGYFPCSDFT SGAPGHLEEH ISQSELTPHL CTNSLHLNVV PPVCLKGSLY CEDCLNKPAR NSIIDAAKVW PNIPPPNTQP APLAVPLCNG CGTKGTGKET TLLLATSLGK AASKFGSPEV AVAGQVLENL PPIGVFWDIE NCSVPSGRSA TAVVQRIREK FFKGHREAEF ICVCDISKEN KEVIQELNNC QVTVAHINAT AKNAADDKLR QSLRRFANTH TAPATVVLVS TDVNFALELS DLRHRHGFHI ILVHKNQASE ALLHHANELI RFEEFISDLP PRLPLKMPQC HTLLYVYNLP ANKDGKSVSN RLRRLSDNCG GKVLSITGCS AILRFINQDS AERAQKRMEN EDVFGNRIIV SFTPKNRELC ETKSSNAIAD KVKSPKKLKN PKLCLIKDAS EQSSSAKATP GKGSQANSGS ATKNTNVKSL QELCRMESKT GHRNSEHQQG HLRLVVPTHG NSSAAVSTPK NSGVAEPVYK TSQKKENLSA RSVTSSPVEK KDKEETVFQV SYPSAFSKLV ASRQVSPLLA SQSWSSRSMS PNLLNRASPL AFNIANSSSE ADCPDPFANG ADVQVSNIDY RLSRKELQQL LQEAFARHGK VKSVELSPHT DYQLKAVVQM ENLQDAIGAV NSLHRYKIGS KKILVSLATG AASKSLSLLS AETMSVLQDA PACCLPLFKF TDIYEKKFGH KLNVSDLYKL TDTVAIREQG NGRLVCLLPS SQARQSPLGS SQSHDGSSTN CSPIIFEELE YHEPVCRQHC SNKDFSEHEF DPDSYKIPFV ILSLKTFAPQ VHSLLQTHEG TVPLLSFPDC YIAEFGDLEV VQENQGGVPL EHFITCVPGV NIATAQNGIK VVKWIHNKPP PPNTDPWLLR SKSPVGNPQL IQFSREVIDL LKSQPSCVIP ISHFIPSYHH HFAKQCRVSD YGYSKLIELL EAVPHVLQIL GMGSKRLLTL THRAQVKRFT QDLLKLLKSQ ASKQVIVREF SQAYHWCFSK DWDVTEYGVC ELIDIVSEIP DTTICLSQQD NEMVICIPKR ERTQDEIERT KQFSKDVVDL LRHQPHFRMP FNKFIPSYHH HFGRQCKLAY YGFTKLLELF EAIPDTLQVL ECGEEKILTL TEVERFKALA AQFVKLLRSQ KDNCLMMTDL LTEYAKTFGY TFRLQDYDVS SISALTQKLC HVVKVADIES GRQIQLINRK SLRSLTAQLL VLLMSWEGTT HLSVEELKRH YESTHNTPLN PCEYGFMTLT ELLKSLPYLV EVFTNDKMEE CVKLTSLYLF AKNVRSLLHT YHYQQIFLHE FSMAYTKYVG ETLQPKTYGH SSVEELLGAI PQVVWIKGHG HKRIVVLKND MKSRLSSLSL SPANHENQPS EGERILEVPE SHTASELKLG ADGSGPSHTE QELLRLTDDS PVDLLCAPVP SCLPSPQLRP DPVILQSADL IQFEERPQEP SEIMILNQEE KMEIPIPGKS KTLTSDSSSS CISAAVPVPP CPSSETSESL LSKDPVESPA KKQPKNRVKL AANFSLAPIT KL
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