About TOG array regulator of axonemal microtubules protein 1
TOG array regulator of axonemal microtubules protein 1 (TOGARAM1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y4F4, 1720 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | TOG array regulator of axonemal microtubules protein 1 |
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| UniProt accession | Q9Y4F4 |
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| Gene | TOGARAM1 |
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| Organism | Homo sapiens |
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| Length | 1720 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- Joubert syndrome 37 · score 0.70
- Joubert syndrome · score 0.61
- ciliopathy · score 0.37
- nicotine dependence symptom count · score 0.30
- body height · score 0.18
- sphingomyelin measurement · score 0.16
- metabolite measurement · score 0.06
- pyelonephritis · score 0.05
- Syndactyly type 2 · score 0.05
- anophthalmia plus syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y4F4-F1 | alphafold | PREDICTED | 61.56 | — |
Amino-acid sequence (1720 residues)
MAAAPSALLL LPPFPVLSTY RLQSRSRPSA PETDDSRVGG IMRGEKNYYF RGAAGDHGSC PTTTSPLASA LLMPSEAVSS SWSESGGGLS GGDEEDTRLL QLLRTARDPS EAFQALQAAL PRRGGRLGFP RRKEALYRAL GRVLVEGGSD EKRLCLQLLS DVLRGQGEAG QLEEAFSLAL LPQLVVSLRE ENPALRKDAL QILHICLKRS PGEVLRTLIQ QGLESTDARL RASTALLLPI LLTTEDLLLG LDLTEVIISL ARKLGDQETE EESETAFSAL QQIGERLGQD RFQSYISRLP SALRRHYNRR LESQFGSQVP YYLELEASGF PEDPLPCAVT LSNSNLKFGI IPQELHSRLL DQEDYKNRTQ AVEELKQVLG KFNPSSTPHS SLVGFISLLY NLLDDSNFKV VHGTLEVLHL LVIRLGEQVQ QFLGPVIAAS VKVLADNKLV IKQEYMKIFL KLMKEVGPQQ VLCLLLEHLK HKHSRVREEV VNICICSLLT YPSEDFDLPK LSFDLAPALV DSKRRVRQAA LEAFAVLASS MGSGKTSILF KAVDTVELQD NGDGVMNAVQ ARLARKTLPR LTEQGFVEYA VLMPSSAGGR SNHLAHGADT DWLLAGNRTQ SAHCHCGDHV RDSMHIYGSY SPTICTRRVL SAGKGKNKLP WENEQPGIMG ENQTSTSKDI EQFSTYDFIP SAKLKLSQGM PVNDDLCFSR KRVSRNLFQN SRDFNPDCLP LCAAGTTGTH QTNLSGKCAQ LGFSQICGKT GSVGSDLQFL GTTSSHQEKV YASLNFGSKT QQTFGSQTEC TSSNGQNPSP GAYILPSYPV SSPRTSPKHT SPLIISPKKS QDNSVNFSNS WPLKSFEGLS KPSPQKKLVS QKSSDPTGRN HGENSQEKPP VQLTPALVRS PSSRRGLNGT KPVPPIPRGI SLLPDKADLS TVGHKKKEPD DIWKCEKDSL PIDLSELNFK DKDLDQEEMH SSLRSLRNSA AKKRAKLSGS TSDLESPDSA MKLDLTMDSP SLSSSPNINS YSESGVYSQE SLTSSLSTTP QGKRIMSDIF PTFGSKPCPT RLSSAKKKIS HIAEQSPSAG SSSNPQQISS FDFTTTKALS EDSVVVVGKG VFGSLSSAPA TCSQSVISSV ENGDTFSIKQ SIEPPSGIYG RSVQQNISSY LDVENEKDAK VSISKSTYNK MRQKRKEEKE LFHNKDCEKK EKNSWERMRH TGTEKMASES ETPTGAISQY KERMPSVTHS PEIMDLSELR PFSKPEIALT EALRLLADED WEKKIEGLNF IRCLAAFHSE ILNTKLHETN FAVVQEVKNL RSGVSRAAVV CLSDLFTYLK KSMDQELDTT VKVLLHKAGE SNTFIREDVD KALRAMVNNV TPARAVVSLI NGGQRYYGRK MLFFMMCHPN FEKMLEKYVP SKDLPYIKDS VRNLQQKGLG EIPLDTPSAK GRRSHTGSVG NTRSSSVSRD AFNSAERAVT EVREVTRKSV PRNSLESAEY LKLITGLLNA KDFRDRINGI KQLLSDTENN QDLVVGNIVK IFDAFKSRLH DSNSKVNLVA LETMHKMIPL LRDHLSPIIN MLIPAIVDNN LNSKNPGIYA AATNVVQALS QHVDNYLLLQ PFCTKAQFLN GKAKQDMTEK LADIVTELYQ RKPHATEQKV LVVLWHLLGN MTNSGSLPGA GGNIRTATAK LSKALFAQMG QNLLNQAASQ PPHIKKSLEE LLDMTILNEL
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