About E3 ubiquitin-protein ligase RNF114
E3 ubiquitin-protein ligase RNF114 (RNF114) is a protein
from Homo sapiens identified by UniProt accession
Q9Y508, 228 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF114 |
|---|
| UniProt accession | Q9Y508 |
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| Gene | RNF114 |
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| Organism | Homo sapiens |
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| Length | 228 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- psoriasis · score 0.25
- age at menopause · score 0.20
- type 2 diabetes mellitus · score 0.20
- clear cell renal carcinoma · score 0.18
- psoriasis vulgaris · score 0.16
- systemic lupus erythematosus · score 0.09
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.07
- thrombocytopenia 4 · score 0.07
- amyotrophic lateral sclerosis · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y508-F1 | alphafold | PREDICTED | 83.62 | — |
Amino-acid sequence (228 residues)
MAAQQRDCGG AAQLAGPAAE ADPLGRFTCP VCLEVYEKPV QVPCGHVFCS ACLQECLKPK KPVCGVCRSA LAPGVRAVEL ERQIESTETS CHGCRKNFFL SKIRSHVATC SKYQNYIMEG VKATIKDASL QPRNVPNRYT FPCPYCPEKN FDQEGLVEHC KLFHSTDTKS VVCPICASMP WGDPNYRSAN FREHIQRRHR FSYDTFVDYD VDEEDMMNQV LQRSIIDQ
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