About Sorting and assembly machinery component 50 homolog
Sorting and assembly machinery component 50 homolog (SAMM50) is a protein
from Homo sapiens identified by UniProt accession
Q9Y512, 469 residues long.
MolForge cross-references it against 0 known binders and
129 disease associations.
Target properties
| Protein name | Sorting and assembly machinery component 50 homolog |
|---|
| UniProt accession | Q9Y512 |
|---|
| Gene | SAMM50 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 469 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (129)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.41
- non-alcoholic fatty liver disease · score 0.26
- triglyceride measurement · score 0.24
- total cholesterol measurement · score 0.23
- osteoprotegerin measurement · score 0.19
- diacylglycerol 38:5 measurement · score 0.18
- diglyceride measurement · score 0.18
- urate measurement · score 0.15
- diacylglycerol 38:3 measurement · score 0.14
- uric acid measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y512-F1 | alphafold | PREDICTED | 85.80 | — |
Amino-acid sequence (469 residues)
MGTVHARSLE PLPSSGPDFG GLGEEAEFVE VEPEAKQEIL ENKDVVVQHV HFDGLGRTKD DIIICEIGDV FKAKNLIEVM RKSHEAREKL LRLGIFRQVD VLIDTCQGDD ALPNGLDVTF EVTELRRLTG SYNTMVGNNE GSMVLGLKLP NLLGRAEKVT FQFSYGTKET SYGLSFFKPR PGNFERNFSV NLYKVTGQFP WSSLRETDRG MSAEYSFPIW KTSHTVKWEG VWRELGCLSR TASFAVRKES GHSLKSSLSH AMVIDSRNSS ILPRRGALLK VNQELAGYTG GDVSFIKEDF ELQLNKQLIF DSVFSASFWG GMLVPIGDKP SSIADRFYLG GPTSIRGFSM HSIGPQSEGD YLGGEAYWAG GLHLYTPLPF RPGQGGFGEL FRTHFFLNAG NLCNLNYGEG PKAHIRKLAE CIRWSYGAGI VLRLGNIARL ELNYCVPMGV QTGDRICDGV QFGAGIRFL
Explore Sorting and assembly machinery component 50 homolog with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets