About DNA-directed RNA polymerase III subunit RPC8
DNA-directed RNA polymerase III subunit RPC8 (POLR3H) is a protein
from Homo sapiens identified by UniProt accession
Q9Y535, 204 residues long.
MolForge cross-references it against 0 known binders and
83 disease associations.
Target properties
| Protein name | DNA-directed RNA polymerase III subunit RPC8 |
|---|
| UniProt accession | Q9Y535 |
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| Gene | POLR3H |
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| Organism | Homo sapiens |
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| Length | 204 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (83)
Diseases linked to this target (Open Targets).
- infantile cerebellar-retinal degeneration · score 0.52
- Leber hereditary optic neuropathy · score 0.48
- neurodegenerative disease · score 0.40
- genetic disorder · score 0.39
- 46,XX gonadal dysgenesis · score 0.38
- primary ovarian insufficiency · score 0.20
- medulloblastoma · score 0.14
- asthma · score 0.09
- alcohol consumption measurement · score 0.09
- smoking cessation · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y535-F1 | alphafold | PREDICTED | 87.99 | — |
Amino-acid sequence (204 residues)
MFVLVEMVDT VRIPPWQFER KLNDSIAEEL NKKLANKVVY NVGLCICLFD ITKLEDAYVF PGDGASHTKV HFRCVVFHPF LDEILIGKIK GCSPEGVHVS LGFFDDILIP PESLQQPAKF DEAEQVWVWE YETEEGAHDL YMDTGEEIRF RVVDESFVDT SPTGPSSADA TTSSEELPKK EAPYTLVGSI SEPGLGLLSW WTSN
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