Leucine-rich repeat-containing protein 42 (LRRC42)

About Leucine-rich repeat-containing protein 42

Leucine-rich repeat-containing protein 42 (LRRC42) is a protein from Homo sapiens identified by UniProt accession Q9Y546, 428 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Leucine-rich repeat-containing protein 42
UniProt accession	Q9Y546
Gene	LRRC42
Organism	Homo sapiens
Length	428 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
hormone measurement · score 0.09
thyroxine measurement · score 0.09
red blood cell density measurement · score 0.04
mean corpuscular hemoglobin concentration · score 0.03
mean corpuscular hemoglobin · score 0.03
erythrocyte count · score 0.03
ulcerative colitis · score 0.01
cancer · score 0.01
bladder transitional cell carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y546-F1	alphafold	PREDICTED	72.56	—

Amino-acid sequence (428 residues)

MSYYLSSENH LDPGPIYMRE NGQLHMVNLA LDGVRSSLQK PRPFRLFPKG FSVELCMNRE DDTARKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN VDHIDSLIGF PEQIAEKLFS AAEARQKFTE PGAGLRALQK FTEAYGSLVL CSLCLRNRYL VISEKLEEIK SFRELTCLDL SCCKLGDEHE LLEHLTNEAL SSVTQLHLKD NCLSDAGVRK MTAPVRVMKR GLENLTLLDL SCNPEITDAG IGYLFSFRKL NCLDISGTGL KDIKTVKHKL QTHIGLVHSK VPLKEFDHSN CKTEGWADQI VLQWERVTAE AVKPRETSEP RAAAQRFYGK RSRAEAPLKC PLADTHMNSS EKLQFYKEKA PDCHGPVLKH EAISSQESKK SKKRPFEESE TEQNNSSQPS KQKYVCLAVE DWDLLNSY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards