Protein phosphatase methylesterase 1 (PPME1)

About Protein phosphatase methylesterase 1

Protein phosphatase methylesterase 1 (PPME1) is a protein from Homo sapiens identified by UniProt accession Q9Y570, 386 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Protein phosphatase methylesterase 1
UniProt accession	Q9Y570
Gene	PPME1
Organism	Homo sapiens
Length	386 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
hepatocellular carcinoma · score 0.07
blood protein measurement · score 0.07
hypertriglyceridemia 2 · score 0.06
glioblastoma multiforme · score 0.05
cholesterol-ester transfer protein deficiency · score 0.05
neoplasm · score 0.05
Fish-eye disease · score 0.05
hypoalphalipoproteinemia, primary, 1 · score 0.04
hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y570-F1	alphafold	PREDICTED	82.62	—

Amino-acid sequence (386 residues)

MSALEKSMHL GRLPSRPPLP GSGGSQSGAK MRMGPGRKRD FSPVPWSQYF ESMEDVEVEN ETGKDTFRVY KSGSEGPVLL LLHGGGHSAL SWAVFTAAII SRVQCRIVAL DLRSHGETKV KNPEDLSAET MAKDVGNVVE AMYGDLPPPI MLIGHSMGGA IAVHTASSNL VPSLLGLCMI DVVEGTAMDA LNSMQNFLRG RPKTFKSLEN AIEWSVKSGQ IRNLESARVS MVGQVKQCEG ITSPEGSKSI VEGIIEEEEE DEEGSESISK RKKEDDMETK KDHPYTWRIE LAKTEKYWDG WFRGLSNLFL SCPIPKLLLL AGVDRLDKDL TIGQMQGKFQ MQVLPQCGHA VHEDAPDKVA EAVATFLIRH RFAEPIGGFQ CVFPGC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards