Ankyrin repeat and SOCS box protein 4 (ASB4)

About Ankyrin repeat and SOCS box protein 4

Ankyrin repeat and SOCS box protein 4 (ASB4) is a protein from Homo sapiens identified by UniProt accession Q9Y574, 426 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Ankyrin repeat and SOCS box protein 4
UniProt accession	Q9Y574
Gene	ASB4
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.38
body mass index · score 0.31
self reported educational attainment · score 0.31
body fat percentage · score 0.30
pancreatic adenocarcinoma · score 0.18
acute myeloid leukemia · score 0.10
familial idiopathic steroid-resistant nephrotic syndrome · score 0.04
focal segmental glomerulosclerosis · score 0.04
hepatocellular carcinoma · score 0.04
lung carcinoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y574-F1	alphafold	PREDICTED	92.69	—

Amino-acid sequence (426 residues)

MDGTTAPVTK SGAAKLVKRN FLEALKSNDF GKLKAILIQR QIDVDTVFEV EDENMVLASY KQGYWLPSYK LKSSWATGLH LSVLFGHVEC LLVLLDHNAT INCRPNGKTP LHVACEMANV DCVKILCDRG AKLNCYSLSG HTALHFCTTP SSILCAKQLV WRGANVNMKT NNQDEETPLH TAAHFGLSEL VAFYVEHGAI VDSVNAHMET PLAIAAYWAL RFKEQEYSTE HHLVCRMLLD YKAEVNARDD DFKSPLHKAA WNCDHVLMHM MLEAGAEANL MDINGCAAIQ YVLKVTSVRP AAQPEICYQL LLNHGAARIY PPQFHKVIQA CHSCPKAIEV VVNAYEHIRW NTKWRRAIPD DDLEKYWDFY HSLFTVCCNS PRTLMHLSRC AIRRTLHNRC HRAIPLLSLP LSLKKYLLLE PEGIIY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards