Ankyrin repeat and SOCS box protein 3 (ASB3)

About Ankyrin repeat and SOCS box protein 3

Ankyrin repeat and SOCS box protein 3 (ASB3) is a protein from Homo sapiens identified by UniProt accession Q9Y575, 518 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Ankyrin repeat and SOCS box protein 3
UniProt accession	Q9Y575
Gene	ASB3
Organism	Homo sapiens
Length	518 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

Mandibular prognathia · score 0.37
Red cell distribution width · score 0.35
neurodegenerative disease · score 0.35
mean corpuscular volume · score 0.34
reticulocyte count · score 0.34
hemoglobin measurement · score 0.32
mean corpuscular hemoglobin concentration · score 0.32
hematocrit · score 0.32
body mass index · score 0.29
mean reticulocyte volume · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y575-F1	alphafold	PREDICTED	90.67	—

Amino-acid sequence (518 residues)

MDFTEAYADT CSTVGLAARE GNVKVLRKLL KKGRSVDVAD NRGWMPIHEA AYHNSVECLQ MLINADSSEN YIKMKTFEGF CALHLAASQG HWKIVQILLE AGADPNATTL EETTPLFLAV ENGQIDVLRL LLQHGANVNG SHSMCGWNSL HQASFQENAE IIKLLLRKGA NKECQDDFGI TPLFVAAQYG KLESLSILIS SGANVNCQAL DKATPLFIAA QEGHTKCVEL LLSSGADPDL YCNEDSWQLP IHAAAQMGHT KILDLLIPLT NRACDTGLNK VSPVYSAVFG GHEDCLEILL RNGYSPDAQA CLVFGFSSPV CMAFQKDCEF FGIVNILLKY GAQINELHLA YCLKYEKFSI FRYFLRKGCS LGPWNHIYEF VNHAIKAQAK YKEWLPHLLV AGFDPLILLC NSWIDSVSID TLIFTLEFTN WKTLAPAVER MLSARASNAW ILQQHIATVP SLTHLCRLEI RSSLKSERLR SDSYISQLPL PRSLHNYLLY EDVLRMYEVP ELAAIQDG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards