Ankyrin repeat and SOCS box protein 1 (ASB1)

About Ankyrin repeat and SOCS box protein 1

Ankyrin repeat and SOCS box protein 1 (ASB1) is a protein from Homo sapiens identified by UniProt accession Q9Y576, 335 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Ankyrin repeat and SOCS box protein 1
UniProt accession	Q9Y576
Gene	ASB1
Organism	Homo sapiens
Length	335 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

circadian rhythm · score 0.35
FEV/FVC ratio · score 0.35
chronic obstructive pulmonary disease · score 0.28
balding measurement · score 0.23
hair shape measurement · score 0.22
body height · score 0.21
clear cell renal carcinoma · score 0.18
forced expiratory volume · score 0.18
Abnormality of refraction · score 0.18
waist-hip ratio · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y576-F1	alphafold	PREDICTED	80.69	—

Amino-acid sequence (335 residues)

MAEGGSPDGR AGPGSAGRNL KEWLREQFCD HPLEHCEDTR LHDAAYVGDL QTLRSLLQEE SYRSRINEKS VWCCGWLPCT PLRIAATAGH GSCVDFLIRK GAEVDLVDVK GQTALYVAVV NGHLESTQIL LEAGADPNGS RHHRSTPVYH ASRVGRADIL KALIRYGADV DVNHHLTPDV QPRFSRRLTS LVVCPLYISA AYHNLQCFRL LLLAGANPDF NCNGPVNTQG FYRGSPGCVM DAVLRHGCEA AFVSLLVEFG ANLNLVKWES LGPESRGRRK VDPEALQVFK EARSVPRTLL CLCRVAVRRA LGKHRLHLIP SLPLPDPIKK FLLHE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards