Protein mab-21-like 2 (MAB21L2)

About Protein mab-21-like 2

Protein mab-21-like 2 (MAB21L2) is a protein from Homo sapiens identified by UniProt accession Q9Y586, 359 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Protein mab-21-like 2
UniProt accession	Q9Y586
Gene	MAB21L2
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

colobomatous microphthalmia-rhizomelic dysplasia syndrome · score 0.81
syndromic microphthalmia · score 0.52
genetic disorder · score 0.17
lobe attachment · score 0.13
systolic blood pressure · score 0.12
mean arterial pressure · score 0.06
monocyte percentage of leukocytes · score 0.06
retinitis pigmentosa · score 0.06
low density lipoprotein cholesterol measurement · score 0.06
actinic keratosis · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y586-F1	alphafold	PREDICTED	94.84	—

Amino-acid sequence (359 residues)

MIAAQAKLVY QLNKYYTERC QARKAAIAKT IREVCKVVSD VLKEVEVQEP RFISSLSEID ARYEGLEVIS PTEFEVVLYL NQMGVFNFVD DGSLPGCAVL KLSDGRKRSM SLWVEFITAS GYLSARKIRS RFQTLVAQAV DKCSYRDVVK MIADTSEVKL RIRERYVVQI TPAFKCTGIW PRSAAQWPMP HIPWPGPNRV AEVKAEGFNL LSKECYSLTG KQSSAESDAW VLQFGEAENR LLMGGCRNKC LSVLKTLRDR HLELPGQPLN NYHMKTLLLY ECEKHPRETD WDESCLGDRL NGILLQLISC LQCRRCPHYF LPNLDLFQGK PHSALESAAK QTWRLAREIL TNPKSLDKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards