About AP-4 complex subunit sigma-1
AP-4 complex subunit sigma-1 (AP4S1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y587, 144 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | AP-4 complex subunit sigma-1 |
|---|
| UniProt accession | Q9Y587 |
|---|
| Gene | AP4S1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 144 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (50)
Diseases linked to this target (Open Targets).
- Severe intellectual disability and progressive spastic paraplegia · score 0.76
- Spastic paraplegia · score 0.54
- genetic disorder · score 0.49
- Global developmental delay · score 0.48
- Seizure · score 0.48
- Intellectual disability · score 0.43
- Neurodevelopmental disorder · score 0.41
- AP-4 deficiency syndrome · score 0.37
- Red cell distribution width · score 0.35
- white matter microstructure measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y587-F1 | alphafold | PREDICTED | 94.65 | — |
Amino-acid sequence (144 residues)
MIKFFLMVNK QGQTRLSKYY EHVDINKRTL LETEVIKSCL SRSNEQCSFI EYKDFKLIYR QYAALFIVVG VNDTENEMAI YEFIHNFVEV LDEYFSRVSE LDIMFNLDKV HIILDEMVLN GCIVETNRAR ILAPLLILDK MSES
Explore AP-4 complex subunit sigma-1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets