About Centrosomal protein of 83 kDa
Centrosomal protein of 83 kDa (CEP83) is a protein
from Homo sapiens identified by UniProt accession
Q9Y592, 701 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Centrosomal protein of 83 kDa |
|---|
| UniProt accession | Q9Y592 |
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| Gene | CEP83 |
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| Organism | Homo sapiens |
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| Length | 701 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- nephronophthisis · score 0.70
- pulse pressure measurement · score 0.46
- Infantile nephronophthisis · score 0.37
- creatinine measurement · score 0.30
- ciliopathy · score 0.30
- vital capacity · score 0.29
- sodium measurement · score 0.28
- chloride measurement · score 0.28
- total blood protein measurement · score 0.27
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y592-F1 | alphafold | PREDICTED | 81.32 | — |
Amino-acid sequence (701 residues)
MVVSTFTDMD TFPNNFPPGG DSGLTGSQSE FQKMLIDERL RCEHHKANYQ TLKAEHTRLQ NEHVKLQNEL KHLFNEKQTQ QEKLQLLLEE LRGELVEKTK DLEEMKLQIL TPQKLELLRA QIQQELETPM RERFRNLDEE VEKYRAVYNK LRYEHTFLKS EFEHQKEEYA RILDEGKIKY ESEIARLEED KEELRNQLLN VDLTKDSKRV EQLAREKVYL CQKLKGLEAE VAELKAEKEN SEAQVENAQR IQVRQLAEMQ ATVRSLEAEK QSANLRAERL EKELQSSSEQ NTFLINKLHK AEREINTLSS KVKELKHSNK LEITDIKLET ARAKSELERE RNKIQSELDG LQSDNEILKA AVEHHKVLLV EKDRELIRKV QAAKEEGYQK LVVLQDEKLE LENRLADLEK MKVEHDVWRQ SEKDQYEEKL RASQMAEEIT RKELQSVRLK LQQQIVTIEN AEKEKNENSD LKQQISSLQI QVTSLAQSEN DLLNSNQMLK EMVERLKQEC RNFRSQAEKA QLEAEKTLEE KQIQWLEEKH KLHERITDRE EKYNQAKEKL QRAAIAQKKR KSLHENKLKR LQEKVEVLEA KKEELETENQ VLNRQNVPFE DYTRLQKRLK DIQRRHNEFR SLILVPNMPP TASINPVSFQ SSAMVPSMEL PFPPHMQEEQ HQRELSLLRK RLEELETTQR KQLEELGSSG E
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