About Leucine-rich repeat flightless-interacting protein 2
Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y608, 721 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Leucine-rich repeat flightless-interacting protein 2 |
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| UniProt accession | Q9Y608 |
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| Gene | LRRFIP2 |
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| Organism | Homo sapiens |
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| Length | 721 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- serum alanine aminotransferase measurement · score 0.29
- platelet component distribution width · score 0.28
- high density lipoprotein cholesterol measurement · score 0.27
- body height · score 0.27
- serum gamma-glutamyl transferase measurement · score 0.27
- cortical thickness · score 0.27
- mean corpuscular volume · score 0.24
- hypothyroidism · score 0.24
- triglyceride measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y608-F1 | alphafold | PREDICTED | 66.94 | — |
Amino-acid sequence (721 residues)
MGTPASGRKR TPVKDRFSAE DEALSNIARE AEARLAAKRA ARAEARDIRM RELERQQKEY SLHSFDRKWG QIQKWLEDSE RARYSHRSSH HRPYLGVEDA LSIRSVGSHR YDMFKDRSSR LSSLNHSYSH SHGMKKRSSD SHKDLLSGLY FDQRNYSSLR HSKPTSAYYT RQSSSLYSDP LATYKSDRAS PTANSGLLRS ASLASLYNGG LYNPYGPRTP SECSYYSSRI SSARSSPGFT NDDTASIVSS DRASRGRRES VVSAADYFSR SNRRGSVVSE VDDISIPDLS SLDEKSDKQY AENYTRPSSR NSASATTPLS GNSSRRGSGD TSSLIDPDTS LSELRDIYDL KDQIQDVEGR YMQGLKELKE SLSEVEEKYK KAMVSNAQLD NEKNNLIYQV DTLKDVIEEQ EEQMAEFYRE NEEKSKELER QKHMCSVLQH KMEELKEGLR QRDELIEEKQ RMQQKIDTMT KEVFDLQETL LWKDKKIGAL EKQKEYIACL RNERDMLREE LADLQETVKT GEKHGLVIIP DGTPNGDVSH EPVAGAITVV SQEAAQVLES AGEGPLDVRL RKLAGEKEEL LSQIRKLKLQ LEEERQKCSR NDGTVGDLAG LQNGSDLQFI EMQRDANRQI SEYKFKLSKA EQDITTLEQS ISRLEGQVLR YKTAAENAEK VEDELKAEKR KLQRELRTAL DKIEEMEMTN SHLAKRLEKM KANRTALLAQ Q
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