Actin-like protein 7B (ACTL7B)

About Actin-like protein 7B

Actin-like protein 7B (ACTL7B) is a protein from Homo sapiens identified by UniProt accession Q9Y614, 415 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.

Target properties

Protein name	Actin-like protein 7B
UniProt accession	Q9Y614
Gene	ACTL7B
Organism	Homo sapiens
Length	415 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (144)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.33
balding measurement · score 0.32
hair shape measurement · score 0.28
neurofibrillary tangles measurement · score 0.22
keratoconus · score 0.22
central corneal thickness · score 0.22
bone quantitative ultrasound measurement · score 0.22
adolescent idiopathic scoliosis · score 0.13
lobe attachment · score 0.13
facial morphology measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y614-F1	alphafold	PREDICTED	87.92	—

Amino-acid sequence (415 residues)

MATRNSPMPL GTAQGDPGEA GTRPGPDASL RDTGAATQLK MKPRKVHKIK AVIIDLGSQY CKCGYAGEPR PTYFISSTVG KRCPEAADAG DTRKWTLVGH ELLNTEAPLK LVNPLKHGIV VDWDCVQDIW EYIFRTAMKI LPEEHAVLVS DPPLSPSSNR EKYAELMFET FGIPAMHVTS QSLLSIYSYG KTSGLVVESG HGVSHVVPIS EGDVLPGLTS RADYAGGDLT NYLMQLLNEA GHAFTDDHLH IIEHIKKKCC YAAFLPEEEL GLVPEELRVD YELPDGKLIT IGQERFRCSE MLFQPSLAGS TQPGLPELTA ACLGRCQDTG FKEEMAANVL LCGGCTMLDG FPERFQRELS LLCPGDSPAV AAAPERKTSV WTGGSILASL QAFQQLWVSK EEFEERGSVA IYSKC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards