Actin-like protein 7A (ACTL7A)

About Actin-like protein 7A

Actin-like protein 7A (ACTL7A) is a protein from Homo sapiens identified by UniProt accession Q9Y615, 435 residues long. MolForge cross-references it against 0 known binders and 104 disease associations.

Target properties

Protein name	Actin-like protein 7A
UniProt accession	Q9Y615
Gene	ACTL7A
Organism	Homo sapiens
Length	435 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (104)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.28
balding measurement · score 0.22
bone quantitative ultrasound measurement · score 0.20
central corneal thickness · score 0.17
keratoconus · score 0.17
neurofibrillary tangles measurement · score 0.16
azoospermia · score 0.10
lobe attachment · score 0.10
facial morphology measurement · score 0.10
adolescent idiopathic scoliosis · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y615-F1	alphafold	PREDICTED	84.55	—

Amino-acid sequence (435 residues)

MWAPPAAIMG DGPTKKVGNQ APLQTQALQT ASLRDGPAKR AVWVRHTSSE PQEPTESKAA KERPKQEVTK AVVVDLGTGY CKCGFAGLPR PTHKISTTVG KPYMETAKTG DNRKETFVGQ ELNNTNVHLK LVNPLRHGII VDWDTVQDIW EYLFRQEMKI APEEHAVLVS DPPLSPHTNR EKYAEMLFEA FNTPAMHIAY QSRLSMYSYG RTSGLVVEVG HGVSYVVPIY EGYPLPSITG RLDYAGSDLT AYLLGLLNSA GNEFTQDQMG IVEDIKKKCC FVALDPIEEK KVPLSEHTIR YVLPDGKEIQ LCQERFLCSE MFFKPSLIKS MQLGLHTQTV SCLNKCDIAL KRDLMGNILL CGGSTMLSGF PNRLQKELSS MCPNDTPQVN VLPERDSAVW TGGSILASLQ GFQPLWVHRF EYEEHGPFFL YRRCF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards