About Interleukin-1 receptor-associated kinase 3
Interleukin-1 receptor-associated kinase 3 (IRAK3) is a protein
from Homo sapiens identified by UniProt accession
Q9Y616, 596 residues long.
MolForge cross-references it against 0 known binders and
255 disease associations.
Target properties
| Protein name | Interleukin-1 receptor-associated kinase 3 |
|---|
| UniProt accession | Q9Y616 |
|---|
| Gene | IRAK3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 596 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (255)
Diseases linked to this target (Open Targets).
- response to ketamine · score 0.31
- thyroid gland adenocarcinoma · score 0.23
- asthma · score 0.23
- CINCA syndrome · score 0.18
- protein measurement · score 0.15
- body height · score 0.12
- Hirschsprung disease · score 0.11
- basophil count · score 0.11
- neoplasm · score 0.10
- breast adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y616-F1 | alphafold | PREDICTED | 71.47 | — |
Amino-acid sequence (596 residues)
MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS SWLDVRHIEK YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH LITNYGAVLS PSEKSYQEGG FPNILFKETA NVTVDNVLIP EHNEKGILLK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY RVEIQNLTYA VKLFKQEKKM QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLI YPYMRNGTLF DRLQCVGDTA PLPWHIRIGI LIGISKAIHY LHNVQPCSVI CGSISSANIL LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK LSIKTDVYSF GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL SFLDKKVPPC PRNFSAKLFC LAGRCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE DDESQNNNLL PSDEGLRIDR MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSCE ESWFPKYIVP SQDLRPYKVN IDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQYKKE
Explore Interleukin-1 receptor-associated kinase 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets