About Glypican-6
Glypican-6 (GPC6) is a protein
from Homo sapiens identified by UniProt accession
Q9Y625, 555 residues long.
MolForge cross-references it against 0 known binders and
233 disease associations.
Target properties
| Protein name | Glypican-6 |
|---|
| UniProt accession | Q9Y625 |
|---|
| Gene | GPC6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 555 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (233)
Diseases linked to this target (Open Targets).
- autosomal recessive omodysplasia · score 0.76
- COVID-19 · score 0.54
- omodysplasia · score 0.52
- heel bone mineral density · score 0.49
- waist-hip ratio · score 0.43
- lean body mass · score 0.42
- chronotype measurement · score 0.42
- wellbeing measurement · score 0.42
- fat body mass · score 0.38
- body weight · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y625-F1 | alphafold | PREDICTED | 81.97 | — |
Amino-acid sequence (555 residues)
MPSWIGAVIL PLLGLLLSLP AGADVKARSC GEVRQAYGAK GFSLADIPYQ EIAGEHLRIC PQEYTCCTTE MEDKLSQQSK LEFENLVEET SHFVRTTFVS RHKKFDEFFR ELLENAEKSL NDMFVRTYGM LYMQNSEVFQ DLFTELKRYY TGGNVNLEEM LNDFWARLLE RMFQLINPQY HFSEDYLECV SKYTDQLKPF GDVPRKLKIQ VTRAFIAART FVQGLTVGRE VANRVSKVSP TPGCIRALMK MLYCPYCRGL PTVRPCNNYC LNVMKGCLAN QADLDTEWNL FIDAMLLVAE RLEGPFNIES VMDPIDVKIS EAIMNMQENS MQVSAKVFQG CGQPKPAPAL RSARSAPENF NTRFRPYNPE ERPTTAAGTS LDRLVTDIKE KLKLSKKVWS ALPYTICKDE SVTAGTSNEE ECWNGHSKAR YLPEIMNDGL TNQINNPEVD VDITRPDTFI RQQIMALRVM TNKLKNAYNG NDVNFQDTSD ESSGSGSGSG CMDDVCPTEF EFVTTEAPAV DPDRREVDSS AAQRGHSLLS WSLTCIVLAL QRLCR
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