About Beta-1,3-N-acetylglucosaminyltransferase radical fringe
Beta-1,3-N-acetylglucosaminyltransferase radical fringe (RFNG) is a protein
from Homo sapiens identified by UniProt accession
Q9Y644, 331 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Beta-1,3-N-acetylglucosaminyltransferase radical fringe |
|---|
| UniProt accession | Q9Y644 |
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| Gene | RFNG |
|---|
| Organism | Homo sapiens |
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| Length | 331 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (135)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.23
- heel bone mineral density · score 0.22
- head and neck squamous cell carcinoma · score 0.21
- gastric adenocarcinoma · score 0.11
- esophageal cancer · score 0.11
- Split hand-split foot malformation · score 0.07
- Robin sequence-oligodactyly syndrome · score 0.06
- Syndactyly type 2 · score 0.06
- syndactyly type 4 · score 0.05
- mesomelic dwarfism-cleft palate-camptodactyly syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y644-F1 | alphafold | PREDICTED | 87.41 | — |
Amino-acid sequence (331 residues)
MSRARGALCR ACLALAAALA ALLLLPLPLP RAPAPARTPA PAPRAPPSRP AAPSLRPDDV FIAVKTTRKN HGPRLRLLLR TWISRARQQT FIFTDGDDPE LELQGGDRVI NTNCSAVRTR QALCCKMSVE YDKFIESGRK WFCHVDDDNY VNARSLLHLL SSFSPSQDVY LGRPSLDHPI EATERVQGGR TVTTVKFWFA TGGAGFCLSR GLALKMSPWA SLGSFMSTAE QVRLPDDCTV GYIVEGLLGA RLLHSPLFHS HLENLQRLPP DTLLQQVTLS HGGPENPHNV VNVAGGFSLH QDPTRFKSIH CLLYPDTDWC PRQKQGAPTS R
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