Carboxypeptidase Q (CPQ)

About Carboxypeptidase Q

Carboxypeptidase Q (CPQ) is a protein from Homo sapiens identified by UniProt accession Q9Y646, 472 residues long. MolForge cross-references it against 0 known binders and 204 disease associations.

Target properties

Protein name	Carboxypeptidase Q
UniProt accession	Q9Y646
Gene	CPQ
Organism	Homo sapiens
Length	472 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (204)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.41
age at first sexual intercourse measurement · score 0.37
Abdominal pain · score 0.31
Headache · score 0.31
Limb pain · score 0.31
appendicular lean mass · score 0.10
Abnormality of refraction · score 0.10
glioblastoma multiforme · score 0.08
migraine disorder · score 0.06
hemoglobin D disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y646-F1	alphafold	PREDICTED	93.69	—

Amino-acid sequence (472 residues)

MKFLIFAFFG GVHLLSLCSG KAICKNGISK RTFEEIKEEI ASCGDVAKAI INLAVYGKAQ NRSYERLALL VDTVGPRLSG SKNLEKAIQI MYQNLQQDGL EKVHLEPVRI PHWERGEESA VMLEPRIHKI AILGLGSSIG TPPEGITAEV LVVTSFDELQ RRASEARGKI VVYNQPYINY SRTVQYRTQG AVEAAKVGAL ASLIRSVASF SIYSPHTGIQ EYQDGVPKIP TACITVEDAE MMSRMASHGI KIVIQLKMGA KTYPDTDSFN TVAEITGSKY PEQVVLVSGH LDSWDVGQGA MDDGGGAFIS WEALSLIKDL GLRPKRTLRL VLWTAEEQGG VGAFQYYQLH KVNISNYSLV MESDAGTFLP TGLQFTGSEK ARAIMEEVMS LLQPLNITQV LSHGEGTDIN FWIQAGVPGA SLLDDLYKYF FFHHSHGDTM TVMDPKQMNV AAAVWAVVSY VVADMEEMLP RS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards