About Transcription factor SOX-21
Transcription factor SOX-21 (SOX21) is a protein
from Homo sapiens identified by UniProt accession
Q9Y651, 276 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Transcription factor SOX-21 |
|---|
| UniProt accession | Q9Y651 |
|---|
| Gene | SOX21 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 276 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (174)
Diseases linked to this target (Open Targets).
- Achilles tendon injury · score 0.30
- PHF-tau measurement · score 0.27
- nose morphology measurement · score 0.23
- prostate adenocarcinoma · score 0.22
- oral squamous cell carcinoma · score 0.20
- lung adenocarcinoma · score 0.19
- gastric carcinoma · score 0.19
- non-small cell lung carcinoma · score 0.19
- gastric adenocarcinoma · score 0.19
- cervical squamous cell carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y651-F1 | alphafold | PREDICTED | 63.14 | — |
Amino-acid sequence (276 residues)
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GGVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL
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