About Adhesion G-protein coupled receptor G1
Adhesion G-protein coupled receptor G1 (ADGRG1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y653, 693 residues long.
MolForge cross-references it against 0 known binders and
227 disease associations.
Target properties
| Protein name | Adhesion G-protein coupled receptor G1 |
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| UniProt accession | Q9Y653 |
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| Gene | ADGRG1 |
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| Organism | Homo sapiens |
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| Length | 693 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (227)
Diseases linked to this target (Open Targets).
- bilateral frontoparietal polymicrogyria · score 0.82
- bilateral perisylvian polymicrogyria · score 0.60
- polymicrogyria · score 0.56
- genetic disorder · score 0.45
- prostate carcinoma · score 0.36
- Global developmental delay · score 0.33
- Visual impairment · score 0.33
- Strabismus · score 0.33
- Intellectual disability, moderate · score 0.33
- Generalized weakness of limb muscles · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y653-F1 | alphafold | PREDICTED | 77.90 | — |
Amino-acid sequence (693 residues)
MTPQSLLQTT LFLLSLLFLV QGAHGRGHRE DFRFCSQRNQ THRSSLHYKP TPDLRISIEN SEEALTVHAP FPAAHPASRS FPDPRGLYHF CLYWNRHAGR LHLLYGKRDF LLSDKASSLL CFQHQEESLA QGPPLLATSV TSWWSPQNIS LPSAASFTFS FHSPPHTAAH NASVDMCELK RDLQLLSQFL KHPQKASRRP SAAPASQQLQ SLESKLTSVR FMGDMVSFEE DRINATVWKL QPTAGLQDLH IHSRQEEEQS EIMEYSVLLP RTLFQRTKGR SGEAEKRLLL VDFSSQALFQ DKNSSQVLGE KVLGIVVQNT KVANLTEPVV LTFQHQLQPK NVTLQCVFWV EDPTLSSPGH WSSAGCETVR RETQTSCFCN HLTYFAVLMV SSVEVDAVHK HYLSLLSYVG CVVSALACLV TIAAYLCSRV PLPCRRKPRD YTIKVHMNLL LAVFLLDTSF LLSEPVALTG SEAGCRASAI FLHFSLLTCL SWMGLEGYNL YRLVVEVFGT YVPGYLLKLS AMGWGFPIFL VTLVALVDVD NYGPIILAVH RTPEGVIYPS MCWIRDSLVS YITNLGLFSL VFLFNMAMLA TMVVQILRLR PHTQKWSHVL TLLGLSLVLG LPWALIFFSF ASGTFQLVVL YLFSIITSFQ GFLIFIWYWS MRLQARGGPS PLKSNSDSAR LPISSGSTSS SRI
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