About Spindlin-1
Spindlin-1 (SPIN1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y657, 262 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Spindlin-1 |
|---|
| UniProt accession | Q9Y657 |
|---|
| Gene | SPIN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 262 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (104)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.40
- body height · score 0.33
- urate measurement · score 0.30
- uric acid measurement · score 0.30
- neurodegenerative disease · score 0.25
- sitting height measurement · score 0.17
- forced expiratory volume · score 0.15
- BMI-adjusted hip circumference · score 0.13
- lean body mass · score 0.12
- fat body mass · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y657-F1 | alphafold | PREDICTED | 81.20 | — |
Amino-acid sequence (262 residues)
MKTPFGKTPG QRSRADAGHA GVSANMMKKR TSHKKHRSSV GPSKPVSQPR RNIVGCRIQH GWKEGNGPVT QWKGTVLDQV PVNPSLYLIK YDGFDCVYGL ELNKDERVSA LEVLPDRVAT SRISDAHLAD TMIGKAVEHM FETEDGSKDE WRGMVLARAP VMNTWFYITY EKDPVLYMYQ LLDDYKEGDL RIMPDSNDSP PAEREPGEVV DSLVGKQVEY AKEDGSKRTG MVIHQVEAKP SVYFIKFDDD FHIYVYDLVK TS
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