About Heparan sulfate glucosamine 3-O-sulfotransferase 4
Heparan sulfate glucosamine 3-O-sulfotransferase 4 (HS3ST4) is a protein
from Homo sapiens identified by UniProt accession
Q9Y661, 456 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Heparan sulfate glucosamine 3-O-sulfotransferase 4 |
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| UniProt accession | Q9Y661 |
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| Gene | HS3ST4 |
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| Organism | Homo sapiens |
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| Length | 456 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- hematologic disease · score 0.29
- PHF-tau measurement · score 0.28
- metabolite measurement · score 0.27
- breast milk measurement · score 0.25
- arterial stiffness measurement · score 0.14
- memory performance · score 0.14
- word list delayed recall measurement · score 0.14
- breast carcinoma · score 0.05
- glioblastoma multiforme · score 0.04
- pancreatic adenocarcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y661-F1 | alphafold | PREDICTED | 74.21 | — |
Amino-acid sequence (456 residues)
MARWPAPPPP PPPPPPLAAP PPPGASAKGP PARKLLFMCT LSLSVTYLCY SLLGGSGSLQ FPLALQESPG AAAEPPPSPP PPSLLPTPVR LGAPSQPPAP PPLDNASHGE PPEPPEQPAA PGTDGWGLPS GGGGAQDAWL RTPLAPSEMI TAQSALPERE AQESSTTDED LAGRRAANGS SERGGAVSTP DYGEKKLPQA LIIGVKKGGT RALLEAIRVH PDVRAVGVEP HFFDRNYEKG LEWYRNVMPK TLDGQITMEK TPSYFVTNEA PKRIHSMAKD IKLIVVVRNP VTRAISDYTQ TLSKKPEIPT FEVLAFKNRT LGLIDASWSA IRIGIYALHL ENWLQYFPLS QILFVSGERL IVDPAGEMAK VQDFLGLKRV VTEKHFYFNK TKGFPCLKKP EDSSAPRCLG KSKGRTHPRI DPDVIHRLRK FYKPFNLMFY QMTGQDFQWE QEEGDK
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