About Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y662, 390 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 |
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| UniProt accession | Q9Y662 |
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| Gene | HS3ST3B1 |
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| Organism | Homo sapiens |
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| Length | 390 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.43
- serum albumin measurement · score 0.35
- cortical surface area measurement · score 0.34
- neurodegenerative disease · score 0.31
- heel bone mineral density · score 0.27
- central corneal thickness · score 0.25
- triiodothyronine measurement · score 0.25
- neuroimaging measurement · score 0.25
- brain measurement · score 0.25
- PHF-tau measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y662-F1 | alphafold | PREDICTED | 81.77 | — |
Amino-acid sequence (390 residues)
MGQRLSGGRS CLDVPGRLLP QPPPPPPPVR RKLALLFAML CVWLYMFLYS CAGSCAAAPG LLLLGSGSRA AHDPPALATA PDGTPPRLPF RAPPATPLAS GKEMAEGAAS PEEQSPEVPD SPSPISSFFS GSGSKQLPQA IIIGVKKGGT RALLEFLRVH PDVRAVGAEP HFFDRSYDKG LAWYRDLMPR TLDGQITMEK TPSYFVTREA PARISAMSKD TKLIVVVRDP VTRAISDYTQ TLSKRPDIPT FESLTFKNRT AGLIDTSWSA IQIGIYAKHL EHWLRHFPIR QMLFVSGERL ISDPAGELGR VQDFLGLKRI ITDKHFYFNK TKGFPCLKKA EGSSRPHCLG KTKGRTHPEI DREVVRRLRE FYRPFNLKFY QMTGHDFGWD
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