About Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 (HS3ST3A1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y663, 406 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 |
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| UniProt accession | Q9Y663 |
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| Gene | HS3ST3A1 |
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| Organism | Homo sapiens |
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| Length | 406 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.36
- white matter hyperintensity measurement · score 0.31
- viral load · score 0.26
- neurodegenerative disease · score 0.16
- lobe attachment · score 0.15
- genetic disorder · score 0.12
- sex hormone-binding globulin measurement · score 0.11
- serum albumin measurement · score 0.08
- beta-thalassemia-X-linked thrombocytopenia syndrome · score 0.04
- dehydrated hereditary stomatocytosis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y663-F1 | alphafold | PREDICTED | 80.36 | — |
Amino-acid sequence (406 residues)
MAPPGPASAL STSAEPLSRS IFRKFLLMLC SLLTSLYVFY CLAERCQTLS GPVVGLSGGG EEAGAPGGGV LAGGPRELAV WPAAAQRKRL LQLPQWRRRR PPAPRDDGEE AAWEEESPGL SGGPGGSGAG STVAEAPPGT LALLLDEGSK QLPQAIIIGV KKGGTRALLE FLRVHPDVRA VGAEPHFFDR SYDKGLAWYR DLMPRTLDGQ ITMEKTPSYF VTREAPARIS AMSKDTKLIV VVRDPVTRAI SDYTQTLSKR PDIPTFESLT FKNRTAGLID TSWSAIQIGI YAKHLEHWLR HFPIRQMLFV SGERLISDPA GELGRVQDFL GLKRIITDKH FYFNKTKGFP CLKKAEGSSR PHCLGKTKGR THPEIDREVV RRLREFYRPF NLKFYQMTGH DFGWDG
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