About Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6) is a protein
from Homo sapiens identified by UniProt accession
Q9Y672, 507 residues long.
MolForge cross-references it against 0 known binders and
61 disease associations.
Target properties
| Protein name | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase |
|---|
| UniProt accession | Q9Y672 |
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| Gene | ALG6 |
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| Organism | Homo sapiens |
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| Length | 507 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (61)
Diseases linked to this target (Open Targets).
- ALG6-congenital disorder of glycosylation 1C · score 0.82
- neurodegenerative disease · score 0.55
- genetic disorder · score 0.41
- congenital disorder of glycosylation type I · score 0.37
- lysosomal storage disease · score 0.18
- congenital disorder of glycosylation · score 0.16
- mean reticulocyte volume · score 0.15
- mean corpuscular hemoglobin · score 0.11
- mean corpuscular volume · score 0.10
- drug use measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y672-F1 | alphafold | PREDICTED | 93.16 | — |
Amino-acid sequence (507 residues)
MEKWYLMTVV VLIGLTVRWT VSLNSYSGAG KPPMFGDYEA QRHWQEITFN LPVKQWYFNS SDNNLQYWGL DYPPLTAYHS LLCAYVAKFI NPDWIALHTS RGYESQAHKL FMRTTVLIAD LLIYIPAVVL YCCCLKEIST KKKIANALCI LLYPGLILID YGHFQYNSVS LGFALWGVLG ISCDCDLLGS LAFCLAINYK QMELYHALPF FCFLLGKCFK KGLKGKGFVL LVKLACIVVA SFVLCWLPFF TEREQTLQVL RRLFPVDRGL FEDKVANIWC SFNVFLKIKD ILPRHIQLIM SFCSTFLSLL PACIKLILQP SSKGFKFTLV SCALSFFLFS FQVHEKSILL VSLPVCLVLS EIPFMSTWFL LVSTFSMLPL LLKDELLMPS VVTTMAFFIA CVTSFSIFEK TSEEELQLKS FSISVRKYLP CFTFLSRIIQ YLFLISVITM VLLTLMTVTL DPPQKLPDLF SVLVCFVSCL NFLFFLVYFN IIIMWDSKSG RNQKKIS
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