Dolichyl-phosphate beta-glucosyltransferase (ALG5)

About Dolichyl-phosphate beta-glucosyltransferase

Dolichyl-phosphate beta-glucosyltransferase (ALG5) is a protein from Homo sapiens identified by UniProt accession Q9Y673, 324 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.

Target properties

Protein name	Dolichyl-phosphate beta-glucosyltransferase
UniProt accession	Q9Y673
Gene	ALG5
Organism	Homo sapiens
Length	324 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (17)

Diseases linked to this target (Open Targets).

Autosomal dominant polycystic kidney disease · score 0.37
neurodegenerative disease · score 0.34
head and neck squamous cell carcinoma · score 0.02
ovarian neoplasm · score 0.00
disease of peritoneum · score 0.00
pancreatic carcinoma · score 0.00
dermatomyositis · score 0.00
infect · score 0.00
infection · score 0.00
neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y673-F1	alphafold	PREDICTED	92.43	—

Amino-acid sequence (324 residues)

MAPLLLQLAV LGAALAAAAL VLISIVAFTT ATKMPALHRH EEEKFFLNAK GQKETLPSIW DSPTKQLSVV VPSYNEEKRL PVMMDEALSY LEKRQKRDPA FTYEVIVVDD GSKDQTSKVA FKYCQKYGSD KVRVITLVKN RGKGGAIRMG IFSSRGEKIL MADADGATKF PDVEKLEKGL NDLQPWPNQM AIACGSRAHL EKESIAQRSY FRTLLMYGFH FLVWFLCVKG IRDTQCGFKL FTREAASRTF SSLHVERWAF DVELLYIAQF FKIPIAEIAV NWTEIEGSKL VPFWSWLQMG KDLLFIRLRY LTGAWRLEQT RKMN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards