About Lipid droplet-regulating VLDL assembly factor AUP1
Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y679, 410 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Lipid droplet-regulating VLDL assembly factor AUP1 |
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| UniProt accession | Q9Y679 |
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| Gene | AUP1 |
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| Organism | Homo sapiens |
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| Length | 410 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- Young adult-onset Parkinsonism · score 0.18
- platelet crit · score 0.12
- platelet count · score 0.09
- neoplasm · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
- IGF-1 measurement · score 0.06
- body height · score 0.05
- appendicular lean mass · score 0.04
- serum urea measurement · score 0.03
- head and neck squamous cell carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y679-F1 | alphafold | PREDICTED | 79.48 | — |
Amino-acid sequence (410 residues)
MELPSGPGPE RLFDSHRLPG DCFLLLVLLL YAPVGFCLLV LRLFLGIHVF LVSCALPDSV LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP SFVCWSRGFM EMNGRGELVE SLKRFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLRPVH RQLGEANEEF ALRVQQLVAK ELGQTGTRLT PADKAEHMKR QRHPRLRPQS AQSSFPPSPG PSPDVQLATL AQRVKEVLPH VPLGVIQRDL AKTGCVDLTI TNLLEGAVAF MPEDITKGTQ SLPTASASKF PSSGPVTPQP TALTFAKSSW ARQESLQERK QALYEYARRR FTERRAQEAD
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