About ADP-ribosylation factor-like protein 5A
ADP-ribosylation factor-like protein 5A (ARL5A) is a protein
from Homo sapiens identified by UniProt accession
Q9Y689, 179 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | ADP-ribosylation factor-like protein 5A |
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| UniProt accession | Q9Y689 |
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| Gene | ARL5A |
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| Organism | Homo sapiens |
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| Length | 179 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (101)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.09
- familial atrial fibrillation · score 0.09
- Romano-Ward syndrome · score 0.08
- Familial short QT syndrome · score 0.08
- hypertrophic cardiomyopathy · score 0.08
- Brugada syndrome · score 0.08
- Familial progressive cardiac conduction defect · score 0.08
- Arrhythmogenic right ventricular dysplasia · score 0.07
- idiopathic dilated cardiomyopathy · score 0.07
- familial sick sinus syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y689-F1 | alphafold | PREDICTED | 92.14 | — |
Amino-acid sequence (179 residues)
MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS NVEEIVINNT RFLMWDIGGQ ESLRSSWNTY YTNTEFVIVV VDSTDRERIS VTREELYKML AHEDLRKAGL LIFANKQDVK ECMTVAEISQ FLKLTSIKDH QWHIQACCAL TGEGLCQGLE WMMSRLKIR
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