About Glucocorticoid modulatory element-binding protein 1
Glucocorticoid modulatory element-binding protein 1 (GMEB1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y692, 573 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Glucocorticoid modulatory element-binding protein 1 |
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| UniProt accession | Q9Y692 |
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| Gene | GMEB1 |
|---|
| Organism | Homo sapiens |
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| Length | 573 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- basophil count · score 0.15
- type 2 diabetes mellitus · score 0.13
- basophil percentage of leukocytes · score 0.11
- hepatocellular carcinoma · score 0.08
- neoplasm · score 0.06
- non-small cell lung carcinoma · score 0.05
- hemoglobin A1 measurement · score 0.04
- body height · score 0.03
- hemoglobin measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y692-F1 | alphafold | PREDICTED | 56.88 | — |
Amino-acid sequence (573 residues)
MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGLFIDGHF YNRIYEAGSE NNTAVVAVET HTIHKIEEGI DTGTIEANED MEIAYPITCG ESKAILLWKK FVCPGINVKC VKFNDQLISP KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM DSGQIDFYQH DKVCSNTCRS TKFDLLISSA RAPVPGQQTS VVQTPTSADG SITQIAISEE SMEEAGLEWN SALTAAVTMA TEEGVKKDSE EISEDTLMFW KGIADVGLME EVVCNIQKEI EELLRGVQQR LIQAPFQVTD AAVLNNVAHT FGLMDTVKKV LDNRRNQVEQ GEEQFLYTLT DLERQLEEQK KQGQDHRLKS QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPPVQQP QFTVISPITI TPVGQSFSMG NIPVATLSQG SSPVTVHTLP SGPQLFRYAT VVSSAKSSSP DTVTIHPSSS LALLSSTAMQ DGSTLGNMTT MVSPVELVAM ESGLTSAIQA VESTSEDGQT IIEIDPAPDP EAEDTEGKAV ILETELRTEE KVVAEMEEHQ HQVHNVEIVV LED
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