Alpha-1,3-galactosyltransferase 2 (A3GALT2)

About Alpha-1,3-galactosyltransferase 2

Alpha-1,3-galactosyltransferase 2 (A3GALT2) is a protein from Homo sapiens identified by UniProt accession U3KPV4, 340 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Alpha-1,3-galactosyltransferase 2
UniProt accession	U3KPV4
Gene	A3GALT2
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
lean body mass · score 0.28
fat body mass · score 0.25
appendicular lean mass · score 0.23
risk-taking behaviour · score 0.22
eosinophil count · score 0.18
body weight · score 0.17
erythrocyte count · score 0.17
eosinophil percentage of leukocytes · score 0.16
whole body water mass · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-U3KPV4-F1	alphafold	PREDICTED	91.26	—

Amino-acid sequence (340 residues)

MALKEGLRAW KRIFWRQILL TLGLLGLFLY GLPKFRHLEA LIPMGVCPSA TMSQLRDNFT GALRPWARPE VLTCTPWGAP IIWDGSFDPD VAKQEARQQN LTIGLTIFAV GRYLEKYLER FLETAEQHFM AGQSVMYYVF TELPGAVPRV ALGPGRRLPV ERVARERRWQ DVSMARMRTL HAALGGLPGR EAHFMFCMDV DQHFSGTFGP EALAESVAQL HSWHYHWPSW LLPFERDAHS AAAMAWGQGD FYNHAAVFGG SVAALRGLTA HCAGGLDWDR ARGLEARWHD ESHLNKFFWL HKPAKVLSPE FCWSPDIGPR AEIRRPRLLW APKGYRLLRN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards