Sperm acrosome membrane-associated protein 6 (SPACA6)

About Sperm acrosome membrane-associated protein 6

Sperm acrosome membrane-associated protein 6 (SPACA6) is a protein from Homo sapiens identified by UniProt accession W5XKT8, 324 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.

Target properties

Protein name	Sperm acrosome membrane-associated protein 6
UniProt accession	W5XKT8
Gene	SPACA6
Organism	Homo sapiens
Length	324 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (101)

Diseases linked to this target (Open Targets).

Genetic chronic primary adrenal insufficiency · score 0.26
monocyte count · score 0.22
body height · score 0.17
monocyte percentage of leukocytes · score 0.16
calcium measurement · score 0.14
sitting height measurement · score 0.12
platelet crit · score 0.11
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
azoospermia · score 0.09
Rare genetic female infertility · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-W5XKT8-F1	alphafold	PREDICTED	86.71	—

Amino-acid sequence (324 residues)

MALLALASAV PSALLALAVF RVPAWACLLC FTTYSERLRI CQMFVGMRSP KLEECEEAFT AAFQGLSDTE INYDERSHLH DTFTQMTHAL QELAAAQGSF EVAFPDAAEK MKKVITQLKE AQACIPPCGL QEFARRFLCS GCYSRVCDLP LDCPVQDVTV TRGDQAMFSC IVNFQLPKEE ITYSWKFAGG GLRTQDLSYF RDMPRAEGYL ARIRPAQLTH RGTFSCVIKQ DQRPLARLYF FLNVTGPPPR AETELQASFR EVLRWAPRDA ELIEPWRPSL GELLARPEAL TPSNLFLLAV LGALASASAT VLAWMFFRWY CSGN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards