bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide

C187H151Cl8F16N39O22 — CID 157311909

IUPACbis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide
SMILESC[C@H]1CCC[C@H]1n1cnc2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc(-c3cncnc3)c21.Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc3ncn(C4CC4)c23)c1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2ccn[nH]2)c2c(c1)ncn2C1CC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2C1CCCC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2C1CCCC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@@H]1COC[C@@H]1O.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@H]1COC[C@@H]1O.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@H]1COC[C@H]1O
InChIInChI=1S/C25H22ClF2N5O2.2C24H20ClF2N5O2.C24H19ClF2N4O2.3C23H18ClF2N5O4.C21H16ClF2N5O2/c1-15-3-2-4-22(15)33-14-31-21-10-16(9-20(23(21)33)17-11-29-13-30-12-17)24(34)32-18-5-7-19(8-6-18)35-25(26,27)28;2*25-24(26,27)34-19-7-5-17(6-8-19)31-23(33)15-9-20(16-11-28-13-29-12-16)22-21(10-15)30-14-32(22)18-3-1-2-4-18;1-14-8-16(12-28-11-14)20-9-15(10-21-22(20)31(13-29-21)18-4-5-18)23(32)30-17-2-6-19(7-3-17)33-24(25,26)27;3*24-23(25,26)35-16-3-1-15(2-4-16)30-22(33)13-5-17(14-7-27-11-28-8-14)21-18(6-13)29-12-31(21)19-9-34-10-20(19)32;22-21(23,24)31-15-5-1-13(2-6-15)27-20(30)12-9-16(17-7-8-26-28-17)19-18(10-12)25-11-29(19)14-3-4-14/h5-15,22H,2-4H2,1H3,(H,32,34);2*5-14,18H,1-4H2,(H,31,33);2-3,6-13,18H,4-5H2,1H3,(H,30,32);3*1-8,11-12,19-20,32H,9-10H2,(H,30,33);1-2,5-11,14H,3-4H2,(H,26,28)(H,27,30)/t15-,22+;;;;2*19-,20+;19-,20-;/m0...100./s1
InChIKeyBDDDIRRAICPFGH-ABXOOUKPSA-N
MW3884.11 g/mol
LogP41.21
Rot. Bonds48

About bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide

bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide (PubChem CID 157311909) has the molecular formula C187H151Cl8F16N39O22 and a molecular weight of 3884.11 g/mol. Its IUPAC name is bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide.

Molecular Properties

Compound Namebis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide
PubChem CID157311909
Molecular FormulaC187H151Cl8F16N39O22
Molecular Weight3884.11 g/mol
Exact Mass3877.91
IUPAC Namebis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide
SMILESC[C@H]1CCC[C@H]1n1cnc2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc(-c3cncnc3)c21.Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc3ncn(C4CC4)c23)c1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2ccn[nH]2)c2c(c1)ncn2C1CC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2C1CCCC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2C1CCCC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@@H]1COC[C@@H]1O.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@H]1COC[C@@H]1O.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@H]1COC[C@H]1O
InChIInChI=1S/C25H22ClF2N5O2.2C24H20ClF2N5O2.C24H19ClF2N4O2.3C23H18ClF2N5O4.C21H16ClF2N5O2/c1-15-3-2-4-22(15)33-14-31-21-10-16(9-20(23(21)33)17-11-29-13-30-12-17)24(34)32-18-5-7-19(8-6-18)35-25(26,27)28;2*25-24(26,27)34-19-7-5-17(6-8-19)31-23(33)15-9-20(16-11-28-13-29-12-16)22-21(10-15)30-14-32(22)18-3-1-2-4-18;1-14-8-16(12-28-11-14)20-9-15(10-21-22(20)31(13-29-21)18-4-5-18)23(32)30-17-2-6-19(7-3-17)33-24(25,26)27;3*24-23(25,26)35-16-3-1-15(2-4-16)30-22(33)13-5-17(14-7-27-11-28-8-14)21-18(6-13)29-12-31(21)19-9-34-10-20(19)32;22-21(23,24)31-15-5-1-13(2-6-15)27-20(30)12-9-16(17-7-8-26-28-17)19-18(10-12)25-11-29(19)14-3-4-14/h5-15,22H,2-4H2,1H3,(H,32,34);2*5-14,18H,1-4H2,(H,31,33);2-3,6-13,18H,4-5H2,1H3,(H,30,32);3*1-8,11-12,19-20,32H,9-10H2,(H,30,33);1-2,5-11,14H,3-4H2,(H,26,28)(H,27,30)/t15-,22+;;;;2*19-,20+;19-,20-;/m0...100./s1
InChIKeyBDDDIRRAICPFGH-ABXOOUKPSA-N
XLogP41.21
TPSA733.83 Ų
H-Bond Donors12
H-Bond Acceptors52
Rotatable Bonds48
Heavy Atoms272
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003884.11
LogP ≤ 541.21
H-Bond Donors ≤ 512
H-Bond Acceptors ≤ 1052

Analyze bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide with MolForge

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Related Compounds

5-[5-(cyclopropanecarbonylamino)-3-pyridinyl]-N-[6-(2-fluorophenoxy)-3-pyridinyl]-1H-indazole-3-carboxamide;5-[5-[(4,4-difluoropiperidin-1-yl)methyl]-3-pyridinyl]-N-[6-(2-fluorophenoxy)-3-pyridinyl]-1H-indazole-3-carboxamide;5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]-3-pyridinyl]-N-[6-(2-fluorophenoxy)-3-pyridinyl]-1H-indazole-3-carboxamide;5-[5-(dimethylcarbamoylamino)-3-pyridinyl]-N-[6-(2-fluorophenoxy)-3-pyridinyl]-1H-indazole-3-carboxamide;N-[6-(3-fluorophenoxy)-3-pyridinyl]-5-[5-[(4-hydroxypiperidin-1-yl)methyl]-3-pyridinyl]-1H-indazole-3-carboxamide;N-[6-(2-fluorophenoxy)-3-pyridinyl]-5-(5-morpholin-4-yl-3-pyridinyl)-1H-indazole-3-carboxamide;N-[6-(2-fluorophenoxy)-3-pyridinyl]-5-(5-piperidin-1-yl-3-pyridinyl)-1H-indazole-3-carboxamide;N-[6-(2-fluorophenoxy)-3-pyridinyl]-5-(5-pyrrolidin-1-yl-3-pyridinyl)-1H-indazole-3-carboxamide
CID 157061672
5-[5-(azetidin-1-ylmethyl)-3-pyridinyl]-N-pyridin-4-yl-1H-indazole-3-carboxamide;5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]-3-pyridinyl]-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide;5-[5-[(4-hydroxypiperidin-1-yl)methyl]-3-pyridinyl]-N-pyridin-4-yl-1H-indazole-3-carboxamide;5-[5-(morpholin-4-ylmethyl)-3-pyridinyl]-N-pyridin-4-yl-1H-indazole-3-carboxamide;5-(5-phenoxy-3-pyridinyl)-N-pyridin-4-yl-1H-indazole-3-carboxamide
CID 157102765
6-(1-amino-3-azabicyclo[3.1.0]hexan-3-yl)-N-[4-[chloro(difluoro)methoxy]phenyl]-5-pyrimidin-5-ylpyridine-3-carboxamide;6-[(1S,5R)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-N-[4-[chloro(difluoro)methoxy]phenyl]-5-pyrimidin-5-ylpyridine-3-carboxamide;6-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-5-(2-methylpyrimidin-5-yl)pyridine-3-carboxamide;6-(4,6-dihydro-1H-pyrrolo[3,4-d]pyrazol-5-yl)-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3S,4S)-3-(dimethylamino)-4-hydroxypyrrolidin-1-yl]-5-pyrimidin-5-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157157075
5-[5-[(4,4-difluoropiperidin-1-yl)methyl]-3-pyridinyl]-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide;5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]-3-pyridinyl]-N-(2-methylpyrimidin-5-yl)-1H-indazole-3-carboxamide;N-[5-[(dimethylamino)methyl]-3-pyridinyl]-5-[5-[(4-hydroxypiperidin-1-yl)methyl]-3-pyridinyl]-1H-indazole-3-carboxamide;N-[5-[(dimethylamino)methyl]-3-pyridinyl]-5-(5-phenoxy-3-pyridinyl)-1H-indazole-3-carboxamide
CID 157405004
4-[(3S,4S)-3-amino-4-hydroxypyrrolidin-1-yl]-N-[4-[chloro(difluoro)methoxy]phenyl]-3-(1H-pyrazol-5-yl)benzamide;6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-3-(1H-pyrazol-5-yl)benzamide;5-(3-cyano-1H-pyrazol-5-yl)-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3S,4S)-3-fluoro-4-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-[5-(hydroxymethyl)-1H-pyrazol-3-yl]-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(1H-pyrazol-5-yl)-6-pyrrolidin-1-yl-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 157422805
5-[5-[(4,4-difluoropiperidin-1-yl)methyl]-3-pyridinyl]-N-[6-(4-methylphenoxy)-3-pyridinyl]-1H-indazole-3-carboxamide;5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]-3-pyridinyl]-N-[6-(4-methylphenoxy)-3-pyridinyl]-1H-indazole-3-carboxamide;N-[6-[2-(dimethylamino)ethylamino]-3-pyridinyl]-5-[5-[(4-hydroxypiperidin-1-yl)methyl]-3-pyridinyl]-1H-indazole-3-carboxamide;N-[6-[2-(dimethylamino)ethylamino]-3-pyridinyl]-5-[5-(morpholin-4-ylmethyl)-3-pyridinyl]-1H-indazole-3-carboxamide
CID 157883110
5-[5-[(4,4-difluoropiperidin-1-yl)methyl]-3-pyridinyl]-N-[6-[2-(dimethylamino)ethyl-methylamino]-3-pyridinyl]-1H-indazole-3-carboxamide;5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]-3-pyridinyl]-N-[6-[2-(dimethylamino)ethyl-methylamino]-3-pyridinyl]-1H-indazole-3-carboxamide;N-[6-[(dimethylamino)methyl]-3-pyridinyl]-5-[5-[(4-hydroxypiperidin-1-yl)methyl]-3-pyridinyl]-1H-indazole-3-carboxamide;N-[6-[(dimethylamino)methyl]-3-pyridinyl]-5-(5-phenoxy-3-pyridinyl)-1H-indazole-3-carboxamide;methane
CID 158624173
N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-imidazol-2-yl)pyridine-3-carboxamide;6-(3-hydroxy-3-methylazetidin-1-yl)-5-(1H-imidazol-2-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-imidazol-2-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;5-(5-methyl-1H-imidazol-2-yl)-6-[(3R)-3-methylpyrrolidin-1-yl]-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 158790696
6-[(3R,4R)-3-amino-4-fluoropyrrolidin-1-yl]-N-[4-[chloro(difluoro)methoxy]phenyl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;4-[(3S,4S)-3-amino-4-hydroxypyrrolidin-1-yl]-N-[4-[chloro(difluoro)methoxy]phenyl]-3-(5-methyl-1H-pyrazol-3-yl)benzamide;4-[(3S,4S)-3-(aminomethyl)-4-hydroxypyrrolidin-1-yl]-N-[4-[chloro(difluoro)methoxy]phenyl]-3-(1H-pyrazol-5-yl)benzamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S,4S)-3-(dimethylamino)-4-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S,4S)-3-fluoro-4-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-[ethyl(2-hydroxyethyl)amino]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-hydroxyethyl(methyl)amino]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 158861263
N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3S)-3-hydroxypiperidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-6-(4-hydroxypiperidin-1-yl)-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;6-(4,7-diazaspiro[2.5]octan-7-yl)-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[2-(hydroxymethyl)morpholin-4-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide
CID 158940017
6-[(3R,4R)-3-amino-4-fluoropyrrolidin-1-yl]-N-[4-[chloro(difluoro)methoxy]phenyl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;4-[(3S,4S)-3-amino-4-hydroxypyrrolidin-1-yl]-N-[4-[chloro(difluoro)methoxy]phenyl]-3-(5-methyl-1H-pyrazol-3-yl)benzamide;6-[(3S,4S)-3-amino-4-methoxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)-N-[4-(trifluoromethoxy)phenyl]pyridine-3-carboxamide;6-[(3S,4S)-3-(aminomethyl)-4-hydroxypyrrolidin-1-yl]-N-[4-[chloro(difluoro)methoxy]phenyl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-3-(1H-pyrazol-5-yl)benzamide
CID 158946379
5-[5-[(4,4-difluoropiperidin-1-yl)methyl]-3-pyridinyl]-N-[6-[2-(dimethylamino)ethyl-methylamino]-3-pyridinyl]-1H-indazole-3-carboxamide;5-[5-[(3,3-difluoropyrrolidin-1-yl)methyl]-3-pyridinyl]-N-[6-[2-(dimethylamino)ethyl-methylamino]-3-pyridinyl]-1H-indazole-3-carboxamide;N-[6-[(dimethylamino)methyl]-3-pyridinyl]-5-[5-[(4-hydroxypiperidin-1-yl)methyl]-3-pyridinyl]-1H-indazole-3-carboxamide;N-[6-[(dimethylamino)methyl]-3-pyridinyl]-5-(5-phenoxy-3-pyridinyl)-1H-indazole-3-carboxamide
CID 159158044

Frequently Asked Questions

What is the IUPAC name of bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide?
The IUPAC name of bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide (CID 157311909) is bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide.
What is the SMILES notation for bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide?
The canonical SMILES for bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide is C[C@H]1CCC[C@H]1n1cnc2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc(-c3cncnc3)c21.Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc3ncn(C4CC4)c23)c1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2ccn[nH]2)c2c(c1)ncn2C1CC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2C1CCCC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2C1CCCC1.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@@H]1COC[C@@H]1O.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@H]1COC[C@@H]1O.O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cc(-c2cncnc2)c2c(c1)ncn2[C@H]1COC[C@H]1O.
What is the InChIKey of bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide?
The InChIKey is BDDDIRRAICPFGH-ABXOOUKPSA-N. The full InChI is InChI=1S/C25H22ClF2N5O2.2C24H20ClF2N5O2.C24H19ClF2N4O2.3C23H18ClF2N5O4.C21H16ClF2N5O2/c1-15-3-2-4-22(15)33-14-31-21-10-16(9-20(23(21)33)17-11-29-13-30-12-17)24(34)32-18-5-7-19(8-6-18)35-25(26,27)28;2*25-24(26,27)34-19-7-5-17(6-8-19)31-23(33)15-9-20(16-11-28-13-29-12-16)22-21(10-15)30-14-32(22)18-3-1-2-4-18;1-14-8-16(12-28-11-14)20-9-15(10-21-22(20)31(13-29-21)18-4-5-18)23(32)30-17-2-6-19(7-3-17)33-24(25,26)27;3*24-23(25,26)35-16-3-1-15(2-4-16)30-22(33)13-5-17(14-7-27-11-28-8-14)21-18(6-13)29-12-31(21)19-9-34-10-20(19)32;22-21(23,24)31-15-5-1-13(2-6-15)27-20(30)12-9-16(17-7-8-26-28-17)19-18(10-12)25-11-29(19)14-3-4-14/h5-15,22H,2-4H2,1H3,(H,32,34);2*5-14,18H,1-4H2,(H,31,33);2-3,6-13,18H,4-5H2,1H3,(H,30,32);3*1-8,11-12,19-20,32H,9-10H2,(H,30,33);1-2,5-11,14H,3-4H2,(H,26,28)(H,27,30)/t15-,22+;;;;2*19-,20+;19-,20-;/m0...100./s1.
What are the key properties of bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide?
bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide has a molecular weight of 3884.11 g/mol, XLogP of 41.21, 48 rotatable bonds, 12 hydrogen bond donors, and 52 hydrogen bond acceptors.
Where does this data come from?
All data for bis(N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopentyl-7-pyrimidin-5-ylbenzimidazole-5-carboxamide);N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(5-methyl-3-pyridinyl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-cyclopropyl-7-(1H-pyrazol-5-yl)benzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4S)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3S,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(3R,4R)-4-hydroxyoxolan-3-yl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide;N-[4-[chloro(difluoro)methoxy]phenyl]-1-[(1R,2S)-2-methylcyclopentyl]-7-pyrimidin-5-ylbenzimidazole-5-carboxamide is sourced from PubChem (CID 157311909), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).