2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

C107H100F18N36O19 — CID 157377154

About 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (PubChem CID 157377154) has the molecular formula C107H100F18N36O19 and a molecular weight of 2536.17 g/mol. Its IUPAC name is 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide.

Molecular Properties

• Compound Name: 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• PubChem CID: 157377154
• Molecular Formula: C107H100F18N36O19
• Molecular Weight: 2536.17 g/mol
• Exact Mass: 2534.77
• IUPAC Name: 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• SMILES: COCCOc1ccncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OC1CCC2(CC1)OCCO2.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OC1CCCOC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OC1CCOCC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1O[C@@H]1CCOC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1O[C@H]1CCOC1
• InChI: InChI=1S/C21H21F3N6O4.2C18H17F3N6O3.2C17H15F3N6O3.C16H15F3N6O3/c22-21(23,24)15-4-8-30-18(28-15)16(17(25)29-30)19(31)27-13-11-26-7-3-14(13)34-12-1-5-20(6-2-12)32-9-10-33-20;19-18(20,21)13-2-6-27-16(25-13)14(15(22)26-27)17(28)24-11-9-23-5-1-12(11)30-10-3-7-29-8-4-10;19-18(20,21)13-4-6-27-16(25-13)14(15(22)26-27)17(28)24-11-8-23-5-3-12(11)30-10-2-1-7-29-9-10;2*18-17(19,20)12-2-5-26-15(24-12)13(14(21)25-26)16(27)23-10-7-22-4-1-11(10)29-9-3-6-28-8-9;1-27-6-7-28-10-2-4-21-8-9(10)22-15(26)12-13(20)24-25-5-3-11(16(17,18)19)23-14(12)25/h3-4,7-8,11-12H,1-2,5-6,9-10H2,(H2,25,29)(H,27,31);1-2,5-6,9-10H,3-4,7-8H2,(H2,22,26)(H,24,28);3-6,8,10H,1-2,7,9H2,(H2,22,26)(H,24,28);2*1-2,4-5,7,9H,3,6,8H2,(H2,21,25)(H,23,27);2-5,8H,6-7H2,1H3,(H2,20,24)(H,22,26)/t;;;2*9-;/m...10./s1
• InChIKey: BKLKJKOJDNBCQK-DGWCOUDDSA-N
• XLogP: 14.41
• TPSA: 709.19 Ų
• H-Bond Donors: 12
• H-Bond Acceptors: 49
• Rotatable Bonds: 26
• Heavy Atoms: 180
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2536.17
LogP ≤ 5	14.41
H-Bond Donors ≤ 5	12
H-Bond Acceptors ≤ 10	49

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'Aliphatic_long_chain', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The IUPAC name of 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (CID 157377154) is 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide.

What is the SMILES notation for 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The canonical SMILES for 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide is COCCOc1ccncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OC1CCC2(CC1)OCCO2.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OC1CCCOC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OC1CCOCC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1O[C@@H]1CCOC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1O[C@H]1CCOC1.

What is the InChIKey of 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The InChIKey is BKLKJKOJDNBCQK-DGWCOUDDSA-N. The full InChI is InChI=1S/C21H21F3N6O4.2C18H17F3N6O3.2C17H15F3N6O3.C16H15F3N6O3/c22-21(23,24)15-4-8-30-18(28-15)16(17(25)29-30)19(31)27-13-11-26-7-3-14(13)34-12-1-5-20(6-2-12)32-9-10-33-20;19-18(20,21)13-2-6-27-16(25-13)14(15(22)26-27)17(28)24-11-9-23-5-1-12(11)30-10-3-7-29-8-4-10;19-18(20,21)13-4-6-27-16(25-13)14(15(22)26-27)17(28)24-11-8-23-5-3-12(11)30-10-2-1-7-29-9-10;2*18-17(19,20)12-2-5-26-15(24-12)13(14(21)25-26)16(27)23-10-7-22-4-1-11(10)29-9-3-6-28-8-9;1-27-6-7-28-10-2-4-21-8-9(10)22-15(26)12-13(20)24-25-5-3-11(16(17,18)19)23-14(12)25/h3-4,7-8,11-12H,1-2,5-6,9-10H2,(H2,25,29)(H,27,31);1-2,5-6,9-10H,3-4,7-8H2,(H2,22,26)(H,24,28);3-6,8,10H,1-2,7,9H2,(H2,22,26)(H,24,28);2*1-2,4-5,7,9H,3,6,8H2,(H2,21,25)(H,23,27);2-5,8H,6-7H2,1H3,(H2,20,24)(H,22,26)/t;;;2*9-;/m...10./s1.

What are the key properties of 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide has a molecular weight of 2536.17 g/mol, XLogP of 14.41, 26 rotatable bonds, 12 hydrogen bond donors, and 49 hydrogen bond acceptors.

Where does this data come from?

All data for 2-amino-N-[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(2-methoxyethoxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-3-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(oxan-4-yloxy)-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3R)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-oxolan-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide is sourced from PubChem (CID 157377154), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).