2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

C79H69Cl4F15N32O10 — CID 158103714

About 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (PubChem CID 158103714) has the molecular formula C79H69Cl4F15N32O10 and a molecular weight of 2053.42 g/mol. Its IUPAC name is 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide.

Molecular Properties

• Compound Name: 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• PubChem CID: 158103714
• Molecular Formula: C79H69Cl4F15N32O10
• Molecular Weight: 2053.42 g/mol
• Exact Mass: 2050.44
• IUPAC Name: 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• SMILES: CN(C)CCOc1cc(Cl)ncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.CN1CCC(Oc2c(Cl)cncc2NC(=O)c2c(N)nn3ccc(C(F)(F)F)nc23)CC1.COc1c(Cl)cncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.COc1cc(C)ncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.COc1cc(Cl)ncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12
• InChI: InChI=1S/C19H19ClF3N7O2.C17H17ClF3N7O2.C15H13F3N6O2.2C14H10ClF3N6O2/c1-29-5-2-10(3-6-29)32-15-11(20)8-25-9-12(15)26-18(31)14-16(24)28-30-7-4-13(19(21,22)23)27-17(14)30;1-27(2)5-6-30-10-7-12(18)23-8-9(10)24-16(29)13-14(22)26-28-4-3-11(17(19,20)21)25-15(13)28;1-7-5-9(26-2)8(6-20-7)21-14(25)11-12(19)23-24-4-3-10(15(16,17)18)22-13(11)24;1-26-7-4-9(15)20-5-6(7)21-13(25)10-11(19)23-24-3-2-8(14(16,17)18)22-12(10)24;1-26-10-6(15)4-20-5-7(10)21-13(25)9-11(19)23-24-3-2-8(14(16,17)18)22-12(9)24/h4,7-10H,2-3,5-6H2,1H3,(H2,24,28)(H,26,31);3-4,7-8H,5-6H2,1-2H3,(H2,22,26)(H,24,29);3-6H,1-2H3,(H2,19,23)(H,21,25);2*2-5H,1H3,(H2,19,23)(H,21,25)
• InChIKey: FPOPYCCSRCLFNA-UHFFFAOYSA-N
• XLogP: 13.25
• TPSA: 543.63 Ų
• H-Bond Donors: 10
• H-Bond Acceptors: 37
• Rotatable Bonds: 19
• Heavy Atoms: 140
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2053.42
LogP ≤ 5	13.25
H-Bond Donors ≤ 5	10
H-Bond Acceptors ≤ 10	37

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': '2-halo_pyridine', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The IUPAC name of 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (CID 158103714) is 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide.

What is the SMILES notation for 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The canonical SMILES for 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide is CN(C)CCOc1cc(Cl)ncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.CN1CCC(Oc2c(Cl)cncc2NC(=O)c2c(N)nn3ccc(C(F)(F)F)nc23)CC1.COc1c(Cl)cncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.COc1cc(C)ncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.COc1cc(Cl)ncc1NC(=O)c1c(N)nn2ccc(C(F)(F)F)nc12.

What is the InChIKey of 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The InChIKey is FPOPYCCSRCLFNA-UHFFFAOYSA-N. The full InChI is InChI=1S/C19H19ClF3N7O2.C17H17ClF3N7O2.C15H13F3N6O2.2C14H10ClF3N6O2/c1-29-5-2-10(3-6-29)32-15-11(20)8-25-9-12(15)26-18(31)14-16(24)28-30-7-4-13(19(21,22)23)27-17(14)30;1-27(2)5-6-30-10-7-12(18)23-8-9(10)24-16(29)13-14(22)26-28-4-3-11(17(19,20)21)25-15(13)28;1-7-5-9(26-2)8(6-20-7)21-14(25)11-12(19)23-24-4-3-10(15(16,17)18)22-13(11)24;1-26-7-4-9(15)20-5-6(7)21-13(25)10-11(19)23-24-3-2-8(14(16,17)18)22-12(10)24;1-26-10-6(15)4-20-5-7(10)21-13(25)9-11(19)23-24-3-2-8(14(16,17)18)22-12(9)24/h4,7-10H,2-3,5-6H2,1H3,(H2,24,28)(H,26,31);3-4,7-8H,5-6H2,1-2H3,(H2,22,26)(H,24,29);3-6H,1-2H3,(H2,19,23)(H,21,25);2*2-5H,1H3,(H2,19,23)(H,21,25).

What are the key properties of 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide has a molecular weight of 2053.42 g/mol, XLogP of 13.25, 19 rotatable bonds, 10 hydrogen bond donors, and 37 hydrogen bond acceptors.

Where does this data come from?

All data for 2-amino-N-[6-chloro-4-[2-(dimethylamino)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(5-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(6-chloro-4-methoxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[5-chloro-4-(1-methylpiperidin-4-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-methoxy-6-methyl-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide is sourced from PubChem (CID 158103714), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).