3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one

C197H244F4N42O15S4 — CID 158208830

IUPAC3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one
SMILESCN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cccc3ncsc13)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnccc1S(C)(=O)=O)C(=O)N2.CN(C)C1(c2cccs2)CCC2(CC1)CN(c1cnc(-c3cccc4c3CC(=O)N4)nc1)C(=O)N2.CN(CCO)c1ncc(N2CC3(CCC(c4cccs4)(N(C)C)CC3)NC2=O)cn1.Cc1cc(-c2ccccn2)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)NC1=O.Cc1cc(C(F)(F)F)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)N(CC(=O)N(C)C)C1=O.Cc1cc(N2CCNC(=O)C2)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)NC1=O.Cc1nc(N2CCOCC2)ncc1N1CC2(CCC(c3ccc(F)cc3)(N(C)C)CC2)NC1=O
InChIInChI=1S/C27H34F3N5O2.C27H31N5O.C26H28N6O2S.C26H34N6O2.C25H33FN6O2.C23H26N4OS.C22H28N4O3S.C21H30N6O2S/c1-19-15-22(27(28,29)30)31-16-21(19)34-18-25(35(24(34)37)17-23(36)32(2)3)11-13-26(14-12-25,33(4)5)20-9-7-6-8-10-20;1-20-17-23(22-11-7-8-16-28-22)29-18-24(20)32-19-26(30-25(32)33)12-14-27(15-13-26,31(2)3)21-9-5-4-6-10-21;1-31(2)26(21-7-4-12-35-21)10-8-25(9-11-26)16-32(24(34)30-25)17-14-27-23(28-15-17)18-5-3-6-20-19(18)13-22(33)29-20;1-19-15-22(31-14-13-27-23(33)17-31)28-16-21(19)32-18-25(29-24(32)34)9-11-26(12-10-25,30(2)3)20-7-5-4-6-8-20;1-18-21(16-27-22(28-18)31-12-14-34-15-13-31)32-17-24(29-23(32)33)8-10-25(11-9-24,30(2)3)19-4-6-20(26)7-5-19;1-26(2)23(17-7-4-3-5-8-17)13-11-22(12-14-23)15-27(21(28)25-22)19-10-6-9-18-20(19)29-16-24-18;1-25(2)22(17-7-5-4-6-8-17)12-10-21(11-13-22)16-26(20(27)24-21)18-15-23-14-9-19(18)30(3,28)29;1-25(2)21(17-5-4-12-30-17)8-6-20(7-9-21)15-27(19(29)24-20)16-13-22-18(23-14-16)26(3)10-11-28/h6-10,15-16H,11-14,17-18H2,1-5H3;4-11,16-18H,12-15,19H2,1-3H3,(H,30,33);3-7,12,14-15H,8-11,13,16H2,1-2H3,(H,29,33)(H,30,34);4-8,15-16H,9-14,17-18H2,1-3H3,(H,27,33)(H,29,34);4-7,16H,8-15,17H2,1-3H3,(H,29,33);3-10,16H,11-15H2,1-2H3,(H,25,28);4-9,14-15H,10-13,16H2,1-3H3,(H,24,27);4-5,12-14,28H,6-11,15H2,1-3H3,(H,24,29)
InChIKeyGBUYJZDRMXVWEG-UHFFFAOYSA-N
MW3644.66 g/mol
LogP28.59
Rot. Bonds34

About 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one

3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one (PubChem CID 158208830) has the molecular formula C197H244F4N42O15S4 and a molecular weight of 3644.66 g/mol. Its IUPAC name is 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one.

Molecular Properties

Compound Name3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one
PubChem CID158208830
Molecular FormulaC197H244F4N42O15S4
Molecular Weight3644.66 g/mol
Exact Mass3641.84
IUPAC Name3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one
SMILESCN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cccc3ncsc13)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnccc1S(C)(=O)=O)C(=O)N2.CN(C)C1(c2cccs2)CCC2(CC1)CN(c1cnc(-c3cccc4c3CC(=O)N4)nc1)C(=O)N2.CN(CCO)c1ncc(N2CC3(CCC(c4cccs4)(N(C)C)CC3)NC2=O)cn1.Cc1cc(-c2ccccn2)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)NC1=O.Cc1cc(C(F)(F)F)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)N(CC(=O)N(C)C)C1=O.Cc1cc(N2CCNC(=O)C2)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)NC1=O.Cc1nc(N2CCOCC2)ncc1N1CC2(CCC(c3ccc(F)cc3)(N(C)C)CC2)NC1=O
InChIInChI=1S/C27H34F3N5O2.C27H31N5O.C26H28N6O2S.C26H34N6O2.C25H33FN6O2.C23H26N4OS.C22H28N4O3S.C21H30N6O2S/c1-19-15-22(27(28,29)30)31-16-21(19)34-18-25(35(24(34)37)17-23(36)32(2)3)11-13-26(14-12-25,33(4)5)20-9-7-6-8-10-20;1-20-17-23(22-11-7-8-16-28-22)29-18-24(20)32-19-26(30-25(32)33)12-14-27(15-13-26,31(2)3)21-9-5-4-6-10-21;1-31(2)26(21-7-4-12-35-21)10-8-25(9-11-26)16-32(24(34)30-25)17-14-27-23(28-15-17)18-5-3-6-20-19(18)13-22(33)29-20;1-19-15-22(31-14-13-27-23(33)17-31)28-16-21(19)32-18-25(29-24(32)34)9-11-26(12-10-25,30(2)3)20-7-5-4-6-8-20;1-18-21(16-27-22(28-18)31-12-14-34-15-13-31)32-17-24(29-23(32)33)8-10-25(11-9-24,30(2)3)19-4-6-20(26)7-5-19;1-26(2)23(17-7-4-3-5-8-17)13-11-22(12-14-23)15-27(21(28)25-22)19-10-6-9-18-20(19)29-16-24-18;1-25(2)22(17-7-5-4-6-8-17)12-10-21(11-13-22)16-26(20(27)24-21)18-15-23-14-9-19(18)30(3,28)29;1-25(2)21(17-5-4-12-30-17)8-6-20(7-9-21)15-27(19(29)24-20)16-13-22-18(23-14-16)26(3)10-11-28/h6-10,15-16H,11-14,17-18H2,1-5H3;4-11,16-18H,12-15,19H2,1-3H3,(H,30,33);3-7,12,14-15H,8-11,13,16H2,1-2H3,(H,29,33)(H,30,34);4-8,15-16H,9-14,17-18H2,1-3H3,(H,27,33)(H,29,34);4-7,16H,8-15,17H2,1-3H3,(H,29,33);3-10,16H,11-15H2,1-2H3,(H,25,28);4-9,14-15H,10-13,16H2,1-3H3,(H,24,27);4-5,12-14,28H,6-11,15H2,1-3H3,(H,24,29)
InChIKeyGBUYJZDRMXVWEG-UHFFFAOYSA-N
XLogP28.59
TPSA582.36 Ų
H-Bond Donors10
H-Bond Acceptors41
Rotatable Bonds34
Heavy Atoms262
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003644.66
LogP ≤ 528.59
H-Bond Donors ≤ 510
H-Bond Acceptors ≤ 1041

Analyze 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one with MolForge

Explore ADMET properties, 3D molecular structure, drug-likeness score, and discover similar compounds using our AI-powered platform.

Launch Full Analysis

Related Compounds

4-(azetidin-1-yl)-2-methyl-5-propan-2-ylpyrimidine;2,4-dimethyl-5-propan-2-ylpyrimidine;4-(4,6-dimethyl-5-propan-2-ylpyrimidin-2-yl)morpholine;2-[methyl-(6-propan-2-yl-3H-indol-2-yl)amino]ethanol;2-[(2-methyl-5-propan-2-ylpyrimidin-4-yl)amino]acetamide;2-methyl-4-(5-propan-2-ylpyrimidin-2-yl)-3H-isoindol-1-one;4-(4-methyl-5-propan-2-ylpyrimidin-2-yl)piperazin-2-one;2-phenyl-5-propan-2-ylthiophene;4-(6-propan-2-yl-3H-indol-2-yl)morpholine;4-propan-2-yl-2-pyridin-4-yl-1,3-thiazole;6-propan-2-ylquinazoline;4-[5-propan-2-yl-4-(trifluoromethyl)pyrimidin-2-yl]piperazin-2-one;1-[4-[5-propan-2-yl-4-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]ethanone;2-propan-2-yl-5-(trifluoromethyl)-1,3,4-thiadiazole
CID 157143412
CID 158064163
CID 158064163
8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one
CID 158314353
CID 158359158
CID 158359158
6-[4-(Benzenesulfonyl)thiophen-2-yl]-2-(4-piperidin-4-ylanilino)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one;2-(4-cyclopentylanilino)-8-[2-(dimethylamino)ethyl]-6-[4-(2-methoxyethylsulfinyl)-1-methylimidazol-2-yl]pyrido[2,3-d]pyrimidin-7-one;6-[1-[2-(dimethylamino)ethylsulfonyl]-5-methylimidazol-4-yl]-8-phenyl-2-(4-piperidin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one;6-[5-(methylidene-oxo-propan-2-yl-lambda6-sulfanyl)-2-pyridinyl]-8-(oxolan-3-yl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one
CID 158815156
CID 159216651
CID 159216651
2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-6-[2-(2-methoxyethylsulfonyl)phenyl]-8-phenylpyrido[2,3-d]pyrimidin-7-one;6-[4-[2-(dimethylamino)ethylsulfonyl]phenyl]-2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one;6-[5-(methylidene-oxo-phenyl-lambda6-sulfanyl)-2-pyridinyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidin-7-one;6-(1-methyl-4-pyridin-4-ylsulfonylimidazol-2-yl)-2-(4-pyrrolidin-3-ylanilino)-8-(1,3-thiazol-2-ylmethyl)pyrido[2,3-d]pyrimidin-7-one
CID 159255765
6-[4-(Benzenesulfonyl)thiophen-2-yl]-2-(4-piperidin-4-ylanilino)-8-(2,2,2-trifluoroethyl)pyrido[2,3-d]pyrimidin-7-one;8-[2-(dimethylamino)ethyl]-6-[4-(2-methoxyethylsulfinyl)-1-methylimidazol-2-yl]-2-(4-pyrrolidin-3-ylanilino)pyrido[2,3-d]pyrimidin-7-one;6-[1-[2-(dimethylamino)ethylsulfonyl]-5-methylimidazol-4-yl]-8-phenyl-2-(4-piperidin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one;6-[5-(methylidene-oxo-propan-2-yl-lambda6-sulfanyl)-2-pyridinyl]-8-(oxolan-3-yl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;molecular hydrogen
CID 159504129
CID 159509396
CID 159509396
CID 159549136
CID 159549136
Bis(8-benzyl-8-(dimethylamino)-3-(2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one);bis(8-benzyl-8-(dimethylamino)-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one);8-(dimethylamino)-3-[2-(4-fluorophenyl)pyrimidin-5-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;4-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-3,5-difluorobenzamide;4-[8-(dimethylamino)-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-3-yl]-3-fluorobenzamide;8-(dimethylamino)-8-phenyl-3-(2-pyridin-2-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;bis(8-(dimethylamino)-8-thiophen-2-yl-3-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one)
CID 159639226
2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-6-[5-methyl-1-(5-methylthiophen-2-yl)imidazol-4-yl]-8-(2-morpholin-4-ylethyl)pyrido[2,3-d]pyrimidin-7-one;8-[1-[dihydroxy(methyl)-lambda4-sulfanyl]piperidin-4-yl]-6-[4-methyl-6-(1-methylpiperidin-2-yl)-3-pyridinyl]-2-(4-pyrrolidin-3-ylanilino)pyrido[2,3-d]pyrimidin-7-one;N-[2-[2-[4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-3-fluoroanilino]-6-[2-methyl-4-(1-methylpiperidin-3-yl)phenyl]-7-oxopyrido[2,3-d]pyrimidin-8-yl]ethyl]-N-methylmethanesulfonamide;6-[3-methyl-5-(1-methylpiperidin-4-yl)-2-pyridinyl]-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]-8-[[2-(trifluoromethyl)phenyl]methyl]pyrido[2,3-d]pyrimidin-7-one
CID 159774240

Frequently Asked Questions

What is the IUPAC name of 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one?
The IUPAC name of 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one (CID 158208830) is 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one.
What is the SMILES notation for 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one?
The canonical SMILES for 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one is CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cccc3ncsc13)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnccc1S(C)(=O)=O)C(=O)N2.CN(C)C1(c2cccs2)CCC2(CC1)CN(c1cnc(-c3cccc4c3CC(=O)N4)nc1)C(=O)N2.CN(CCO)c1ncc(N2CC3(CCC(c4cccs4)(N(C)C)CC3)NC2=O)cn1.Cc1cc(-c2ccccn2)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)NC1=O.Cc1cc(C(F)(F)F)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)N(CC(=O)N(C)C)C1=O.Cc1cc(N2CCNC(=O)C2)ncc1N1CC2(CCC(c3ccccc3)(N(C)C)CC2)NC1=O.Cc1nc(N2CCOCC2)ncc1N1CC2(CCC(c3ccc(F)cc3)(N(C)C)CC2)NC1=O.
What is the InChIKey of 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one?
The InChIKey is GBUYJZDRMXVWEG-UHFFFAOYSA-N. The full InChI is InChI=1S/C27H34F3N5O2.C27H31N5O.C26H28N6O2S.C26H34N6O2.C25H33FN6O2.C23H26N4OS.C22H28N4O3S.C21H30N6O2S/c1-19-15-22(27(28,29)30)31-16-21(19)34-18-25(35(24(34)37)17-23(36)32(2)3)11-13-26(14-12-25,33(4)5)20-9-7-6-8-10-20;1-20-17-23(22-11-7-8-16-28-22)29-18-24(20)32-19-26(30-25(32)33)12-14-27(15-13-26,31(2)3)21-9-5-4-6-10-21;1-31(2)26(21-7-4-12-35-21)10-8-25(9-11-26)16-32(24(34)30-25)17-14-27-23(28-15-17)18-5-3-6-20-19(18)13-22(33)29-20;1-19-15-22(31-14-13-27-23(33)17-31)28-16-21(19)32-18-25(29-24(32)34)9-11-26(12-10-25,30(2)3)20-7-5-4-6-8-20;1-18-21(16-27-22(28-18)31-12-14-34-15-13-31)32-17-24(29-23(32)33)8-10-25(11-9-24,30(2)3)19-4-6-20(26)7-5-19;1-26(2)23(17-7-4-3-5-8-17)13-11-22(12-14-23)15-27(21(28)25-22)19-10-6-9-18-20(19)29-16-24-18;1-25(2)22(17-7-5-4-6-8-17)12-10-21(11-13-22)16-26(20(27)24-21)18-15-23-14-9-19(18)30(3,28)29;1-25(2)21(17-5-4-12-30-17)8-6-20(7-9-21)15-27(19(29)24-20)16-13-22-18(23-14-16)26(3)10-11-28/h6-10,15-16H,11-14,17-18H2,1-5H3;4-11,16-18H,12-15,19H2,1-3H3,(H,30,33);3-7,12,14-15H,8-11,13,16H2,1-2H3,(H,29,33)(H,30,34);4-8,15-16H,9-14,17-18H2,1-3H3,(H,27,33)(H,29,34);4-7,16H,8-15,17H2,1-3H3,(H,29,33);3-10,16H,11-15H2,1-2H3,(H,25,28);4-9,14-15H,10-13,16H2,1-3H3,(H,24,27);4-5,12-14,28H,6-11,15H2,1-3H3,(H,24,29).
What are the key properties of 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one?
3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one has a molecular weight of 3644.66 g/mol, XLogP of 28.59, 34 rotatable bonds, 10 hydrogen bond donors, and 41 hydrogen bond acceptors.
Where does this data come from?
All data for 3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one is sourced from PubChem (CID 158208830), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).