8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one

C199H243ClF7N37O15S2 — CID 158314353

IUPAC8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one
SMILESCN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(-c3cccc4c3CC(=O)N4)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(S(C)(=O)=O)cn1)C(=O)N2CC1CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cccc3c1CC(=O)N3)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(F)c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1nnc(C(F)(F)F)s1)C(=O)N2.CN(CCO)C1=Nc2cc(N3CC4(CCC(c5ccccc5)(N(C)C)CC4)NC3=O)ccc2C1.Cc1cc(C(F)(F)F)ncc1N1CC2(CCC(c3cccc(Cl)c3)(N(C)C)CC2)NC1=O.Cc1cc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cnc1N1CCOCC1
InChIInChI=1S/C29H31N5O2.C27H35N5O2.C26H35N5O2.C26H34N4O3S.C25H32FN5O2.C24H28N4O2.C23H26ClF3N4O.C19H22F3N5OS/c1-33(2)29(21-7-4-3-5-8-21)15-13-28(14-16-29)19-34(27(36)32-28)25-12-11-20(18-30-25)22-9-6-10-24-23(22)17-26(35)31-24;1-30(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-32(25(34)29-26)22-10-9-20-17-24(28-23(20)18-22)31(3)15-16-33;1-20-17-22(18-27-23(20)30-13-15-33-16-14-30)31-19-25(28-24(31)32)9-11-26(12-10-25,29(2)3)21-7-5-4-6-8-21;1-28(2)26(21-7-5-4-6-8-21)15-13-25(14-16-26)19-29(24(31)30(25)18-20-9-10-20)23-12-11-22(17-27-23)34(3,32)33;1-29(2)25(19-6-4-3-5-7-19)10-8-24(9-11-25)18-31(23(32)28-24)20-16-21(26)22(27-17-20)30-12-14-33-15-13-30;1-27(2)24(17-7-4-3-5-8-17)13-11-23(12-14-24)16-28(22(30)26-23)20-10-6-9-19-18(20)15-21(29)25-19;1-15-11-19(23(25,26)27)28-13-18(15)31-14-21(29-20(31)32)7-9-22(10-8-21,30(2)3)16-5-4-6-17(24)12-16;1-26(2)18(13-6-4-3-5-7-13)10-8-17(9-11-18)12-27(15(28)23-17)16-25-24-14(29-16)19(20,21)22/h3-12,18H,13-17,19H2,1-2H3,(H,31,35)(H,32,36);4-10,18,33H,11-17,19H2,1-3H3,(H,29,34);4-8,17-18H,9-16,19H2,1-3H3,(H,28,32);4-8,11-12,17,20H,9-10,13-16,18-19H2,1-3H3;3-7,16-17H,8-15,18H2,1-2H3,(H,28,32);3-10H,11-16H2,1-2H3,(H,25,29)(H,26,30);4-6,11-13H,7-10,14H2,1-3H3,(H,29,32);3-7H,8-12H2,1-2H3,(H,23,28)
InChIKeyGOBPUOXFGGUZQT-UHFFFAOYSA-N
MW3625.95 g/mol
LogP31.53
Rot. Bonds32

About 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one

8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one (PubChem CID 158314353) has the molecular formula C199H243ClF7N37O15S2 and a molecular weight of 3625.95 g/mol. Its IUPAC name is 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one.

Molecular Properties

Compound Name8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one
PubChem CID158314353
Molecular FormulaC199H243ClF7N37O15S2
Molecular Weight3625.95 g/mol
Exact Mass3622.84
IUPAC Name8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one
SMILESCN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(-c3cccc4c3CC(=O)N4)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(S(C)(=O)=O)cn1)C(=O)N2CC1CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cccc3c1CC(=O)N3)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(F)c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1nnc(C(F)(F)F)s1)C(=O)N2.CN(CCO)C1=Nc2cc(N3CC4(CCC(c5ccccc5)(N(C)C)CC4)NC3=O)ccc2C1.Cc1cc(C(F)(F)F)ncc1N1CC2(CCC(c3cccc(Cl)c3)(N(C)C)CC2)NC1=O.Cc1cc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cnc1N1CCOCC1
InChIInChI=1S/C29H31N5O2.C27H35N5O2.C26H35N5O2.C26H34N4O3S.C25H32FN5O2.C24H28N4O2.C23H26ClF3N4O.C19H22F3N5OS/c1-33(2)29(21-7-4-3-5-8-21)15-13-28(14-16-29)19-34(27(36)32-28)25-12-11-20(18-30-25)22-9-6-10-24-23(22)17-26(35)31-24;1-30(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-32(25(34)29-26)22-10-9-20-17-24(28-23(20)18-22)31(3)15-16-33;1-20-17-22(18-27-23(20)30-13-15-33-16-14-30)31-19-25(28-24(31)32)9-11-26(12-10-25,29(2)3)21-7-5-4-6-8-21;1-28(2)26(21-7-5-4-6-8-21)15-13-25(14-16-26)19-29(24(31)30(25)18-20-9-10-20)23-12-11-22(17-27-23)34(3,32)33;1-29(2)25(19-6-4-3-5-7-19)10-8-24(9-11-25)18-31(23(32)28-24)20-16-21(26)22(27-17-20)30-12-14-33-15-13-30;1-27(2)24(17-7-4-3-5-8-17)13-11-23(12-14-24)16-28(22(30)26-23)20-10-6-9-19-18(20)15-21(29)25-19;1-15-11-19(23(25,26)27)28-13-18(15)31-14-21(29-20(31)32)7-9-22(10-8-21,30(2)3)16-5-4-6-17(24)12-16;1-26(2)18(13-6-4-3-5-7-13)10-8-17(9-11-18)12-27(15(28)23-17)16-25-24-14(29-16)19(20,21)22/h3-12,18H,13-17,19H2,1-2H3,(H,31,35)(H,32,36);4-10,18,33H,11-17,19H2,1-3H3,(H,29,34);4-8,17-18H,9-16,19H2,1-3H3,(H,28,32);4-8,11-12,17,20H,9-10,13-16,18-19H2,1-3H3;3-7,16-17H,8-15,18H2,1-2H3,(H,28,32);3-10H,11-16H2,1-2H3,(H,25,29)(H,26,30);4-6,11-13H,7-10,14H2,1-3H3,(H,29,32);3-7H,8-12H2,1-2H3,(H,23,28)
InChIKeyGOBPUOXFGGUZQT-UHFFFAOYSA-N
XLogP31.53
TPSA519.19 Ų
H-Bond Donors10
H-Bond Acceptors35
Rotatable Bonds32
Heavy Atoms261
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003625.95
LogP ≤ 531.53
H-Bond Donors ≤ 510
H-Bond Acceptors ≤ 1035

Analyze 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one with MolForge

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Related Compounds

3-(1,3-benzothiazol-7-yl)-8-(dimethylamino)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-(4-fluorophenyl)-3-(4-methyl-2-morpholin-4-ylpyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[4-methyl-6-(3-oxopiperazin-1-yl)-3-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methyl-6-pyridin-2-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(4-methylsulfonyl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;2-[8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-2-oxo-8-phenyl-1,3-diazaspiro[4.5]decan-1-yl]-N,N-dimethylacetamide;8-(dimethylamino)-3-[2-(2-oxo-1,3-dihydroindol-4-yl)pyrimidin-5-yl]-8-thiophen-2-yl-1,3-diazaspiro[4.5]decan-2-one
CID 158208830
CID 158359158
CID 158359158
2-[4-(3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl)anilino]-8-(cyclopropylmethyl)-6-[5-methyl-2-(1-methylpyrrol-2-yl)-1,3-thiazol-4-yl]pyrido[2,3-d]pyrimidin-7-one;6-[2-chloro-4-(2-methylpyrazol-3-yl)phenyl]-8-(oxolan-3-yl)-2-[4-piperazin-1-yl-3-(trifluoromethyl)anilino]pyrido[2,3-d]pyrimidin-7-one;8-ethyl-2-[3-fluoro-4-(2-methylpiperazin-1-yl)anilino]-6-(2-fluoro-4-pyridin-3-ylphenyl)pyrido[2,3-d]pyrimidin-7-one;2-[3-fluoro-4-(3-methylpiperazin-1-yl)anilino]-6-(4-methyl-2-pyrazin-2-ylpyrimidin-5-yl)-8-(1-methylsulfanylpiperidin-4-yl)pyrido[2,3-d]pyrimidin-7-one;6-(5-methyl-2-pyridin-2-ylpyrimidin-4-yl)-2-[4-(4-methylthiomorpholin-2-yl)anilino]-8-[[2-(trifluoromethyl)phenyl]methyl]pyrido[2,3-d]pyrimidin-7-one;dihydrate
CID 159424582
CID 159509396
CID 159509396
CID 160602082
CID 160602082
CID 161525660
CID 161525660

Frequently Asked Questions

What is the IUPAC name of 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one?
The IUPAC name of 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one (CID 158314353) is 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one.
What is the SMILES notation for 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one?
The canonical SMILES for 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one is CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(-c3cccc4c3CC(=O)N4)cn1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1ccc(S(C)(=O)=O)cn1)C(=O)N2CC1CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cccc3c1CC(=O)N3)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1cnc(N3CCOCC3)c(F)c1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(c1nnc(C(F)(F)F)s1)C(=O)N2.CN(CCO)C1=Nc2cc(N3CC4(CCC(c5ccccc5)(N(C)C)CC4)NC3=O)ccc2C1.Cc1cc(C(F)(F)F)ncc1N1CC2(CCC(c3cccc(Cl)c3)(N(C)C)CC2)NC1=O.Cc1cc(N2CC3(CCC(c4ccccc4)(N(C)C)CC3)NC2=O)cnc1N1CCOCC1.
What is the InChIKey of 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one?
The InChIKey is GOBPUOXFGGUZQT-UHFFFAOYSA-N. The full InChI is InChI=1S/C29H31N5O2.C27H35N5O2.C26H35N5O2.C26H34N4O3S.C25H32FN5O2.C24H28N4O2.C23H26ClF3N4O.C19H22F3N5OS/c1-33(2)29(21-7-4-3-5-8-21)15-13-28(14-16-29)19-34(27(36)32-28)25-12-11-20(18-30-25)22-9-6-10-24-23(22)17-26(35)31-24;1-30(2)27(21-7-5-4-6-8-21)13-11-26(12-14-27)19-32(25(34)29-26)22-10-9-20-17-24(28-23(20)18-22)31(3)15-16-33;1-20-17-22(18-27-23(20)30-13-15-33-16-14-30)31-19-25(28-24(31)32)9-11-26(12-10-25,29(2)3)21-7-5-4-6-8-21;1-28(2)26(21-7-5-4-6-8-21)15-13-25(14-16-26)19-29(24(31)30(25)18-20-9-10-20)23-12-11-22(17-27-23)34(3,32)33;1-29(2)25(19-6-4-3-5-7-19)10-8-24(9-11-25)18-31(23(32)28-24)20-16-21(26)22(27-17-20)30-12-14-33-15-13-30;1-27(2)24(17-7-4-3-5-8-17)13-11-23(12-14-24)16-28(22(30)26-23)20-10-6-9-19-18(20)15-21(29)25-19;1-15-11-19(23(25,26)27)28-13-18(15)31-14-21(29-20(31)32)7-9-22(10-8-21,30(2)3)16-5-4-6-17(24)12-16;1-26(2)18(13-6-4-3-5-7-13)10-8-17(9-11-18)12-27(15(28)23-17)16-25-24-14(29-16)19(20,21)22/h3-12,18H,13-17,19H2,1-2H3,(H,31,35)(H,32,36);4-10,18,33H,11-17,19H2,1-3H3,(H,29,34);4-8,17-18H,9-16,19H2,1-3H3,(H,28,32);4-8,11-12,17,20H,9-10,13-16,18-19H2,1-3H3;3-7,16-17H,8-15,18H2,1-2H3,(H,28,32);3-10H,11-16H2,1-2H3,(H,25,29)(H,26,30);4-6,11-13H,7-10,14H2,1-3H3,(H,29,32);3-7H,8-12H2,1-2H3,(H,23,28).
What are the key properties of 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one?
8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one has a molecular weight of 3625.95 g/mol, XLogP of 31.53, 32 rotatable bonds, 10 hydrogen bond donors, and 35 hydrogen bond acceptors.
Where does this data come from?
All data for 8-(3-chlorophenyl)-8-(dimethylamino)-3-[4-methyl-6-(trifluoromethyl)-3-pyridinyl]-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-(5-methylsulfonyl-2-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-fluoro-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[2-[2-hydroxyethyl(methyl)amino]-3H-indol-6-yl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(5-methyl-6-morpholin-4-yl-3-pyridinyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-(2-oxo-1,3-dihydroindol-4-yl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-3-[5-(2-oxo-1,3-dihydroindol-4-yl)-2-pyridinyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-1,3-diazaspiro[4.5]decan-2-one is sourced from PubChem (CID 158314353), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).