8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine

C127H114ClF7N28O8 — CID 158211798

About 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine

8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine (PubChem CID 158211798) has the molecular formula C127H114ClF7N28O8 and a molecular weight of 2328.94 g/mol. Its IUPAC name is 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine.

Molecular Properties

• Compound Name: 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine
• PubChem CID: 158211798
• Molecular Formula: C127H114ClF7N28O8
• Molecular Weight: 2328.94 g/mol
• Exact Mass: 2326.90
• IUPAC Name: 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine
• SMILES: COc1c(F)ccc(F)c1CCc1ccc(-c2cccnc2C)c2nncn12.COc1cc(C)cc(F)c1CCc1ccc(-c2ccc(C#N)nc2C)c2nncn12.COc1cccc(F)c1CCc1ccc(-c2cc(Cl)cnc2C)c2nncn12.COc1cccc(F)c1CCc1ccc(-c2cnccn2)c2nncn12.COc1ncc(-c2ccc(CCc3c(F)cc(C)cc3OC)n3cnnc23)c(C)n1.COc1ncc(-c2ccc(CCc3c(F)cccc3OC)n3cnnc23)c(C)n1
• InChI: InChI=1S/C23H20FN5O.C22H22FN5O2.C21H18ClFN4O.C21H18F2N4O.C21H20FN5O2.C19H16FN5O/c1-14-10-21(24)20(22(11-14)30-3)9-6-17-5-8-19(23-28-26-13-29(17)23)18-7-4-16(12-25)27-15(18)2;1-13-9-19(23)17(20(10-13)29-3)8-6-15-5-7-16(21-27-25-12-28(15)21)18-11-24-22(30-4)26-14(18)2;1-13-18(10-14(22)11-24-13)16-8-6-15(27-12-25-26-21(16)27)7-9-17-19(23)4-3-5-20(17)28-2;1-13-15(4-3-11-24-13)16-7-5-14(27-12-25-26-21(16)27)6-8-17-18(22)9-10-19(23)20(17)28-2;1-13-17(11-23-21(25-13)29-3)15-9-7-14(27-12-24-26-20(15)27)8-10-16-18(22)5-4-6-19(16)28-2;1-26-18-4-2-3-16(20)14(18)7-5-13-6-8-15(17-11-21-9-10-22-17)19-24-23-12-25(13)19/h4-5,7-8,10-11,13H,6,9H2,1-3H3;5,7,9-12H,6,8H2,1-4H3;3-6,8,10-12H,7,9H2,1-2H3;3-5,7,9-12H,6,8H2,1-2H3;4-7,9,11-12H,8,10H2,1-3H3;2-4,6,8-12H,5,7H2,1H3
• InChIKey: GCEAVFPDSMFDSJ-UHFFFAOYSA-N
• XLogP: 23.37
• TPSA: 394.78 Ų
• H-Bond Acceptors: 36
• Rotatable Bonds: 32
• Heavy Atoms: 171
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2328.94
LogP ≤ 5	23.37
H-Bond Donors ≤ 5	0
H-Bond Acceptors ≤ 10	36

Frequently Asked Questions

What is the IUPAC name of 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine?

The IUPAC name of 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine (CID 158211798) is 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine.

What is the SMILES notation for 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine?

The canonical SMILES for 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine is COc1c(F)ccc(F)c1CCc1ccc(-c2cccnc2C)c2nncn12.COc1cc(C)cc(F)c1CCc1ccc(-c2ccc(C#N)nc2C)c2nncn12.COc1cccc(F)c1CCc1ccc(-c2cc(Cl)cnc2C)c2nncn12.COc1cccc(F)c1CCc1ccc(-c2cnccn2)c2nncn12.COc1ncc(-c2ccc(CCc3c(F)cc(C)cc3OC)n3cnnc23)c(C)n1.COc1ncc(-c2ccc(CCc3c(F)cccc3OC)n3cnnc23)c(C)n1.

What is the InChIKey of 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine?

The InChIKey is GCEAVFPDSMFDSJ-UHFFFAOYSA-N. The full InChI is InChI=1S/C23H20FN5O.C22H22FN5O2.C21H18ClFN4O.C21H18F2N4O.C21H20FN5O2.C19H16FN5O/c1-14-10-21(24)20(22(11-14)30-3)9-6-17-5-8-19(23-28-26-13-29(17)23)18-7-4-16(12-25)27-15(18)2;1-13-9-19(23)17(20(10-13)29-3)8-6-15-5-7-16(21-27-25-12-28(15)21)18-11-24-22(30-4)26-14(18)2;1-13-18(10-14(22)11-24-13)16-8-6-15(27-12-25-26-21(16)27)7-9-17-19(23)4-3-5-20(17)28-2;1-13-15(4-3-11-24-13)16-7-5-14(27-12-25-26-21(16)27)6-8-17-18(22)9-10-19(23)20(17)28-2;1-13-17(11-23-21(25-13)29-3)15-9-7-14(27-12-24-26-20(15)27)8-10-16-18(22)5-4-6-19(16)28-2;1-26-18-4-2-3-16(20)14(18)7-5-13-6-8-15(17-11-21-9-10-22-17)19-24-23-12-25(13)19/h4-5,7-8,10-11,13H,6,9H2,1-3H3;5,7,9-12H,6,8H2,1-4H3;3-6,8,10-12H,7,9H2,1-2H3;3-5,7,9-12H,6,8H2,1-2H3;4-7,9,11-12H,8,10H2,1-3H3;2-4,6,8-12H,5,7H2,1H3.

What are the key properties of 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine?

8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine has a molecular weight of 2328.94 g/mol, XLogP of 23.37, 32 rotatable bonds, 0 hydrogen bond donors, and 36 hydrogen bond acceptors.

Where does this data come from?

All data for 8-(5-chloro-2-methyl-3-pyridinyl)-5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(3,6-difluoro-2-methoxyphenyl)ethyl]-8-(2-methyl-3-pyridinyl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[5-[2-(2-fluoro-6-methoxy-4-methylphenyl)ethyl]-[1,2,4]triazolo[4,3-a]pyridin-8-yl]-6-methylpyridine-2-carbonitrile;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-(2-methoxy-4-methylpyrimidin-5-yl)-[1,2,4]triazolo[4,3-a]pyridine;5-[2-(2-fluoro-6-methoxyphenyl)ethyl]-8-pyrazin-2-yl-[1,2,4]triazolo[4,3-a]pyridine is sourced from PubChem (CID 158211798), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).