8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one

C101H119Cl4F11N6O15 — CID 158268964

About 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one

8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one (PubChem CID 158268964) has the molecular formula C101H119Cl4F11N6O15 and a molecular weight of 2007.88 g/mol. Its IUPAC name is 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one.

Molecular Properties

• Compound Name: 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one
• PubChem CID: 158268964
• Molecular Formula: C101H119Cl4F11N6O15
• Molecular Weight: 2007.88 g/mol
• Exact Mass: 2004.73
• IUPAC Name: 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one
• SMILES: COCCc1cc(C(=O)CCC2(O)CCCC(F)(F)C2)c2c(C(F)(F)F)cccn12.COCCc1cc(C(=O)CCC2(O)CCCC(F)(F)C2)c2c(Cl)cccn12.COCCc1cc(C(=O)CCCC2(O)CCCC2)c2c(Cl)cccn12.O=C(CCC1(O)CCC(F)(F)CC1)c1cc(C2CCOC2)n2cccc(Cl)c12.O=C(NCC1CCC(F)(F)CC1)c1cc(C2(O)COC2)n2cccc(Cl)c12
• InChI: InChI=1S/C21H24ClF2NO3.C21H24F5NO3.C20H24ClF2NO3.C20H26ClNO3.C19H21ClF2N2O3/c22-16-2-1-10-25-17(14-4-11-28-13-14)12-15(19(16)25)18(26)3-5-20(27)6-8-21(23,24)9-7-20;1-30-11-6-14-12-15(18-16(21(24,25)26)4-2-10-27(14)18)17(28)5-9-19(29)7-3-8-20(22,23)13-19;1-27-11-6-14-12-15(18-16(21)4-2-10-24(14)18)17(25)5-9-19(26)7-3-8-20(22,23)13-19;1-25-13-8-15-14-16(19-17(21)6-5-12-22(15)19)18(23)7-4-11-20(24)9-2-3-10-20;20-14-2-1-7-24-15(18(26)10-27-11-18)8-13(16(14)24)17(25)23-9-12-3-5-19(21,22)6-4-12/h1-2,10,12,14,27H,3-9,11,13H2;2,4,10,12,29H,3,5-9,11,13H2,1H3;2,4,10,12,26H,3,5-9,11,13H2,1H3;5-6,12,14,24H,2-4,7-11,13H2,1H3;1-2,7-8,12,26H,3-6,9-11H2,(H,23,25)
• InChIKey: GIUJLIOMJTUJNS-UHFFFAOYSA-N
• XLogP: 22.54
• TPSA: 266.73 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 20
• Rotatable Bonds: 31
• Heavy Atoms: 137
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2007.88
LogP ≤ 5	22.54
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	20

Frequently Asked Questions

What is the IUPAC name of 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one?

The IUPAC name of 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one (CID 158268964) is 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one.

What is the SMILES notation for 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one?

The canonical SMILES for 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one is COCCc1cc(C(=O)CCC2(O)CCCC(F)(F)C2)c2c(C(F)(F)F)cccn12.COCCc1cc(C(=O)CCC2(O)CCCC(F)(F)C2)c2c(Cl)cccn12.COCCc1cc(C(=O)CCCC2(O)CCCC2)c2c(Cl)cccn12.O=C(CCC1(O)CCC(F)(F)CC1)c1cc(C2CCOC2)n2cccc(Cl)c12.O=C(NCC1CCC(F)(F)CC1)c1cc(C2(O)COC2)n2cccc(Cl)c12.

What is the InChIKey of 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one?

The InChIKey is GIUJLIOMJTUJNS-UHFFFAOYSA-N. The full InChI is InChI=1S/C21H24ClF2NO3.C21H24F5NO3.C20H24ClF2NO3.C20H26ClNO3.C19H21ClF2N2O3/c22-16-2-1-10-25-17(14-4-11-28-13-14)12-15(19(16)25)18(26)3-5-20(27)6-8-21(23,24)9-7-20;1-30-11-6-14-12-15(18-16(21(24,25)26)4-2-10-27(14)18)17(28)5-9-19(29)7-3-8-20(22,23)13-19;1-27-11-6-14-12-15(18-16(21)4-2-10-24(14)18)17(25)5-9-19(26)7-3-8-20(22,23)13-19;1-25-13-8-15-14-16(19-17(21)6-5-12-22(15)19)18(23)7-4-11-20(24)9-2-3-10-20;20-14-2-1-7-24-15(18(26)10-27-11-18)8-13(16(14)24)17(25)23-9-12-3-5-19(21,22)6-4-12/h1-2,10,12,14,27H,3-9,11,13H2;2,4,10,12,29H,3,5-9,11,13H2,1H3;2,4,10,12,26H,3,5-9,11,13H2,1H3;5-6,12,14,24H,2-4,7-11,13H2,1H3;1-2,7-8,12,26H,3-6,9-11H2,(H,23,25).

What are the key properties of 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one?

8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one has a molecular weight of 2007.88 g/mol, XLogP of 22.54, 31 rotatable bonds, 6 hydrogen bond donors, and 20 hydrogen bond acceptors.

Where does this data come from?

All data for 8-chloro-N-[(4,4-difluorocyclohexyl)methyl]-3-(3-hydroxyoxetan-3-yl)indolizine-1-carboxamide;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-3-(3,3-difluoro-1-hydroxycyclohexyl)propan-1-one;1-[8-chloro-3-(2-methoxyethyl)indolizin-1-yl]-4-(1-hydroxycyclopentyl)butan-1-one;1-[8-chloro-3-(oxolan-3-yl)indolizin-1-yl]-3-(4,4-difluoro-1-hydroxycyclohexyl)propan-1-one;3-(3,3-difluoro-1-hydroxycyclohexyl)-1-[3-(2-methoxyethyl)-8-(trifluoromethyl)indolizin-1-yl]propan-1-one is sourced from PubChem (CID 158268964), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).