2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide

C139H122Cl2F25N27O16S6 — CID 158553543

About 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide

2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide (PubChem CID 158553543) has the molecular formula C139H122Cl2F25N27O16S6 and a molecular weight of 3164.94 g/mol. Its IUPAC name is 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide.

Molecular Properties

• Compound Name: 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide
• PubChem CID: 158553543
• Molecular Formula: C139H122Cl2F25N27O16S6
• Molecular Weight: 3164.94 g/mol
• Exact Mass: 3161.69
• IUPAC Name: 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide
• SMILES: CC(C)(NS(=O)(=O)c1ccc(-c2c(C#N)c3ccc(OC(F)F)cc3n2-c2ncccn2)nc1)C(F)(F)F.CC1(NS(=O)(=O)c2ccc(-c3c(C#N)c4cc(Cl)c(OC(F)F)cc4n3C3CCC3)nc2)CC1.C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(C4CC4)cc3n2C2CCCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(C4CC4)cc3n2C2CCCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(OC(F)F)cc3n2C2CCC2)nc1)C(F)(F)F.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2cc(OC(F)F)c(Cl)cc12
• InChI: InChI=1S/2C25H24F4N4O2S.C23H21ClF2N4O3S.C23H17F5N6O3S.C22H18F6N4O3S.C21H18ClF4N5O3S/c2*1-14(25(27,28)29)32-36(34,35)17-8-9-22(31-13-17)24-20(12-30)19-10-21(26)18(15-6-7-15)11-23(19)33(24)16-4-2-3-5-16;1-23(7-8-23)29-34(31,32)14-5-6-18(28-12-14)21-16(11-27)15-9-17(24)20(33-22(25)26)10-19(15)30(21)13-3-2-4-13;1-22(2,23(26,27)28)33-38(35,36)14-5-7-17(32-12-14)19-16(11-29)15-6-4-13(37-20(24)25)10-18(15)34(19)21-30-8-3-9-31-21;1-11(22(26,27)28)31-36(33,34)13-5-6-17(30-10-13)20-15(9-29)14-7-16(23)19(35-21(24)25)8-18(14)32(20)12-3-2-4-12;22-16-4-14-15(8-27)19(31(12-2-1-3-12)17(14)5-18(16)34-21(25)26)20-28-9-13(10-29-20)35(32,33)30-11(6-23)7-24/h2*8-11,13-16,32H,2-7H2,1H3;5-6,9-10,12-13,22,29H,2-4,7-8H2,1H3;3-10,12,20,33H,1-2H3;5-8,10-12,21,31H,2-4H2,1H3;4-5,9-12,21,30H,1-3,6-7H2/t2*14-;;;11-;/m10..0./s1
• InChIKey: HPZVMMZRBKDAQF-FMWQOIGPSA-N
• XLogP: 31.64
• TPSA: 602.27 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 37
• Rotatable Bonds: 42
• Heavy Atoms: 215
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	3164.94
LogP ≤ 5	31.64
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	37

Frequently Asked Questions

What is the IUPAC name of 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide?

The IUPAC name of 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide (CID 158553543) is 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide.

What is the SMILES notation for 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide?

The canonical SMILES for 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide is CC(C)(NS(=O)(=O)c1ccc(-c2c(C#N)c3ccc(OC(F)F)cc3n2-c2ncccn2)nc1)C(F)(F)F.CC1(NS(=O)(=O)c2ccc(-c3c(C#N)c4cc(Cl)c(OC(F)F)cc4n3C3CCC3)nc2)CC1.C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(C4CC4)cc3n2C2CCCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(C4CC4)cc3n2C2CCCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(OC(F)F)cc3n2C2CCC2)nc1)C(F)(F)F.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2cc(OC(F)F)c(Cl)cc12.

What is the InChIKey of 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide?

The InChIKey is HPZVMMZRBKDAQF-FMWQOIGPSA-N. The full InChI is InChI=1S/2C25H24F4N4O2S.C23H21ClF2N4O3S.C23H17F5N6O3S.C22H18F6N4O3S.C21H18ClF4N5O3S/c2*1-14(25(27,28)29)32-36(34,35)17-8-9-22(31-13-17)24-20(12-30)19-10-21(26)18(15-6-7-15)11-23(19)33(24)16-4-2-3-5-16;1-23(7-8-23)29-34(31,32)14-5-6-18(28-12-14)21-16(11-27)15-9-17(24)20(33-22(25)26)10-19(15)30(21)13-3-2-4-13;1-22(2,23(26,27)28)33-38(35,36)14-5-7-17(32-12-14)19-16(11-29)15-6-4-13(37-20(24)25)10-18(15)34(19)21-30-8-3-9-31-21;1-11(22(26,27)28)31-36(33,34)13-5-6-17(30-10-13)20-15(9-29)14-7-16(23)19(35-21(24)25)8-18(14)32(20)12-3-2-4-12;22-16-4-14-15(8-27)19(31(12-2-1-3-12)17(14)5-18(16)34-21(25)26)20-28-9-13(10-29-20)35(32,33)30-11(6-23)7-24/h2*8-11,13-16,32H,2-7H2,1H3;5-6,9-10,12-13,22,29H,2-4,7-8H2,1H3;3-10,12,20,33H,1-2H3;5-8,10-12,21,31H,2-4H2,1H3;4-5,9-12,21,30H,1-3,6-7H2/t2*14-;;;11-;/m10..0./s1.

What are the key properties of 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide?

2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide has a molecular weight of 3164.94 g/mol, XLogP of 31.64, 42 rotatable bonds, 6 hydrogen bond donors, and 37 hydrogen bond acceptors.

Where does this data come from?

All data for 2-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-[5-chloro-3-cyano-1-cyclobutyl-6-(difluoromethoxy)indol-2-yl]-N-(1-methylcyclopropyl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-6-cyclopropyl-5-fluoroindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-6-(difluoromethoxy)-1-pyrimidin-2-ylindol-2-yl]-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide is sourced from PubChem (CID 158553543), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).