6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide

C136H133F19N26O12S6 — CID 159502531

About 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide

6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide (PubChem CID 159502531) has the molecular formula C136H133F19N26O12S6 and a molecular weight of 2877.09 g/mol. Its IUPAC name is 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide.

Molecular Properties

• Compound Name: 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide
• PubChem CID: 159502531
• Molecular Formula: C136H133F19N26O12S6
• Molecular Weight: 2877.09 g/mol
• Exact Mass: 2874.86
• IUPAC Name: 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide
• SMILES: Cc1c(F)cc2c(c1F)c(C#N)c(-c1ccc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCC1.Cc1c(F)cc2c(c1F)c(C#N)c(-c1ccc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCCC1.Cc1c(F)cc2c(c1F)c(C#N)c(-c1ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn1)n2C1CCCC1.Cc1ccc2c(C#N)c(-c3ncc(S(=O)(=O)NC(CF)CF)cn3)n(C3CCC3)c2c1F.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn1)n2C1CCCCC1.Cc1ccc2c(c1)c(C#N)c(-c1ncc(S(=O)(=O)N[C@@H](C)C3CC3)cn1)n2CC1CC1
• InChI: InChI=1S/C24H25F3N4O2S.C23H21F5N4O2S.C23H22F4N4O2S.C23H25N5O2S.C22H20F4N4O2S.C21H20F3N5O2S/c1-15-8-11-22-19(12-15)20(13-28)23(31(22)17-6-4-3-5-7-17)21-10-9-18(14-29-21)34(32,33)30-16(2)24(25,26)27;1-12-17(24)9-19-20(21(12)25)16(10-29)22(32(19)14-5-3-4-6-14)18-8-7-15(11-30-18)35(33,34)31-13(2)23(26,27)28;1-13-18(26)8-20-21(22(13)27)17(11-28)23(31(20)15-4-2-3-5-15)19-7-6-16(12-29-19)34(32,33)30-14(9-24)10-25;1-14-3-8-21-19(9-14)20(10-24)22(28(21)13-16-4-5-16)23-25-11-18(12-26-23)31(29,30)27-15(2)17-6-7-17;1-12-17(25)7-19-20(21(12)26)16(10-27)22(30(19)14-3-2-4-14)18-6-5-15(11-28-18)33(31,32)29-13(8-23)9-24;1-12-5-6-16-17(9-25)20(29(14-3-2-4-14)19(16)18(12)24)21-26-10-15(11-27-21)32(30,31)28-13(7-22)8-23/h8-12,14,16-17,30H,3-7H2,1-2H3;7-9,11,13-14,31H,3-6H2,1-2H3;6-8,12,14-15,30H,2-5,9-10H2,1H3;3,8-9,11-12,15-17,27H,4-7,13H2,1-2H3;5-7,11,13-14,29H,2-4,8-9H2,1H3;5-6,10-11,13-14,28H,2-4,7-8H2,1H3/t16-;13-;;15-;;/m00.0../s1
• InChIKey: LZOLIWAHDXSYHK-ZLTHWYFSSA-N
• XLogP: 27.95
• TPSA: 552.46 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 32
• Rotatable Bonds: 38
• Heavy Atoms: 199
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2877.09
LogP ≤ 5	27.95
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	32

Frequently Asked Questions

What is the IUPAC name of 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide?

The IUPAC name of 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide (CID 159502531) is 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide.

What is the SMILES notation for 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide?

The canonical SMILES for 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide is Cc1c(F)cc2c(c1F)c(C#N)c(-c1ccc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCC1.Cc1c(F)cc2c(c1F)c(C#N)c(-c1ccc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCCC1.Cc1c(F)cc2c(c1F)c(C#N)c(-c1ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn1)n2C1CCCC1.Cc1ccc2c(C#N)c(-c3ncc(S(=O)(=O)NC(CF)CF)cn3)n(C3CCC3)c2c1F.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn1)n2C1CCCCC1.Cc1ccc2c(c1)c(C#N)c(-c1ncc(S(=O)(=O)N[C@@H](C)C3CC3)cn1)n2CC1CC1.

What is the InChIKey of 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide?

The InChIKey is LZOLIWAHDXSYHK-ZLTHWYFSSA-N. The full InChI is InChI=1S/C24H25F3N4O2S.C23H21F5N4O2S.C23H22F4N4O2S.C23H25N5O2S.C22H20F4N4O2S.C21H20F3N5O2S/c1-15-8-11-22-19(12-15)20(13-28)23(31(22)17-6-4-3-5-7-17)21-10-9-18(14-29-21)34(32,33)30-16(2)24(25,26)27;1-12-17(24)9-19-20(21(12)25)16(10-29)22(32(19)14-5-3-4-6-14)18-8-7-15(11-30-18)35(33,34)31-13(2)23(26,27)28;1-13-18(26)8-20-21(22(13)27)17(11-28)23(31(20)15-4-2-3-5-15)19-7-6-16(12-29-19)34(32,33)30-14(9-24)10-25;1-14-3-8-21-19(9-14)20(10-24)22(28(21)13-16-4-5-16)23-25-11-18(12-26-23)31(29,30)27-15(2)17-6-7-17;1-12-17(25)7-19-20(21(12)26)16(10-27)22(30(19)14-3-2-4-14)18-6-5-15(11-28-18)33(31,32)29-13(8-23)9-24;1-12-5-6-16-17(9-25)20(29(14-3-2-4-14)19(16)18(12)24)21-26-10-15(11-27-21)32(30,31)28-13(7-22)8-23/h8-12,14,16-17,30H,3-7H2,1-2H3;7-9,11,13-14,31H,3-6H2,1-2H3;6-8,12,14-15,30H,2-5,9-10H2,1H3;3,8-9,11-12,15-17,27H,4-7,13H2,1-2H3;5-7,11,13-14,29H,2-4,8-9H2,1H3;5-6,10-11,13-14,28H,2-4,7-8H2,1H3/t16-;13-;;15-;;/m00.0../s1.

What are the key properties of 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide?

6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide has a molecular weight of 2877.09 g/mol, XLogP of 27.95, 38 rotatable bonds, 6 hydrogen bond donors, and 32 hydrogen bond acceptors.

Where does this data come from?

All data for 6-(3-cyano-1-cyclobutyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-4,6-difluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-[3-cyano-1-(cyclopropylmethyl)-5-methylindol-2-yl]-N-[(1S)-1-cyclopropylethyl]pyrimidine-5-sulfonamide is sourced from PubChem (CID 159502531), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).