N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide

C156H144F9N47O10 — CID 159872743

IUPACN-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide
SMILESCCc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.CNC(=O)Nc1cc2cc(-c3cnn(C)c3)nc(N)c2cn1.COc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3CC3(F)F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cn1cc(-c2cc3cc(NC(=O)C4C[C@@H]4F)ncc3c(N)n2)cn1.Cn1cc(-c2cc3cc(NC(=O)[C@@H]4C[C@@H]4F)ncc3c(N)n2)cn1.Cn1cc(-c2cc3cc(NC(=O)[C@@H]4C[C@H]4F)ncc3c(N)n2)cn1
InChIInChI=1S/C19H16F2N4O.C19H18FN5O.C19H17FN4O2.C19H17FN4O.C18H16FN5O.3C16H15FN6O.C14H15N7O/c1-10-4-2-3-5-12(10)15-6-11-7-16(23-9-13(11)17(22)24-15)25-18(26)14-8-19(14,20)21;1-2-15-11(4-3-5-22-15)16-6-10-7-17(23-9-13(10)18(21)24-16)25-19(26)12-8-14(12)20;1-26-16-5-3-2-4-11(16)15-6-10-7-17(22-9-13(10)18(21)23-15)24-19(25)12-8-14(12)20;1-10-4-2-3-5-12(10)16-6-11-7-17(22-9-14(11)18(21)23-16)24-19(25)13-8-15(13)20;1-9-11(3-2-4-21-9)15-5-10-6-16(22-8-13(10)17(20)23-15)24-18(25)12-7-14(12)19;3*1-23-7-9(5-20-23)13-2-8-3-14(19-6-11(8)15(18)21-13)22-16(24)10-4-12(10)17;1-16-14(22)20-12-4-8-3-11(9-5-18-21(2)7-9)19-13(15)10(8)6-17-12/h2-7,9,14H,8H2,1H3,(H2,22,24)(H,23,25,26);3-7,9,12,14H,2,8H2,1H3,(H2,21,24)(H,23,25,26);2-7,9,12,14H,8H2,1H3,(H2,21,23)(H,22,24,25);2-7,9,13,15H,8H2,1H3,(H2,21,23)(H,22,24,25);2-6,8,12,14H,7H2,1H3,(H2,20,23)(H,22,24,25);3*2-3,5-7,10,12H,4H2,1H3,(H2,18,21)(H,19,22,24);3-7H,1-2H3,(H2,15,19)(H2,16,17,20,22)/t;2*12-,14+;13-,15+;12-,14+;10?,12-;10-,12+;10-,12-;/m.1111011./s1
InChIKeyNSNCPJKLQQKPKO-YPDJWMGSSA-N
MW3008.17 g/mol
LogP23.55
Rot. Bonds28

About N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide

N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide (PubChem CID 159872743) has the molecular formula C156H144F9N47O10 and a molecular weight of 3008.17 g/mol. Its IUPAC name is N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide.

Molecular Properties

Compound NameN-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide
PubChem CID159872743
Molecular FormulaC156H144F9N47O10
Molecular Weight3008.17 g/mol
Exact Mass3006.21
IUPAC NameN-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide
SMILESCCc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.CNC(=O)Nc1cc2cc(-c3cnn(C)c3)nc(N)c2cn1.COc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3CC3(F)F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cn1cc(-c2cc3cc(NC(=O)C4C[C@@H]4F)ncc3c(N)n2)cn1.Cn1cc(-c2cc3cc(NC(=O)[C@@H]4C[C@@H]4F)ncc3c(N)n2)cn1.Cn1cc(-c2cc3cc(NC(=O)[C@@H]4C[C@H]4F)ncc3c(N)n2)cn1
InChIInChI=1S/C19H16F2N4O.C19H18FN5O.C19H17FN4O2.C19H17FN4O.C18H16FN5O.3C16H15FN6O.C14H15N7O/c1-10-4-2-3-5-12(10)15-6-11-7-16(23-9-13(11)17(22)24-15)25-18(26)14-8-19(14,20)21;1-2-15-11(4-3-5-22-15)16-6-10-7-17(23-9-13(10)18(21)24-16)25-19(26)12-8-14(12)20;1-26-16-5-3-2-4-11(16)15-6-10-7-17(22-9-13(10)18(21)23-15)24-19(25)12-8-14(12)20;1-10-4-2-3-5-12(10)16-6-11-7-17(22-9-14(11)18(21)23-16)24-19(25)13-8-15(13)20;1-9-11(3-2-4-21-9)15-5-10-6-16(22-8-13(10)17(20)23-15)24-18(25)12-7-14(12)19;3*1-23-7-9(5-20-23)13-2-8-3-14(19-6-11(8)15(18)21-13)22-16(24)10-4-12(10)17;1-16-14(22)20-12-4-8-3-11(9-5-18-21(2)7-9)19-13(15)10(8)6-17-12/h2-7,9,14H,8H2,1H3,(H2,22,24)(H,23,25,26);3-7,9,12,14H,2,8H2,1H3,(H2,21,24)(H,23,25,26);2-7,9,12,14H,8H2,1H3,(H2,21,23)(H,22,24,25);2-7,9,13,15H,8H2,1H3,(H2,21,23)(H,22,24,25);2-6,8,12,14H,7H2,1H3,(H2,20,23)(H,22,24,25);3*2-3,5-7,10,12H,4H2,1H3,(H2,18,21)(H,19,22,24);3-7H,1-2H3,(H2,15,19)(H2,16,17,20,22)/t;2*12-,14+;13-,15+;12-,14+;10?,12-;10-,12+;10-,12-;/m.1111011./s1
InChIKeyNSNCPJKLQQKPKO-YPDJWMGSSA-N
XLogP23.55
TPSA846.42 Ų
H-Bond Donors19
H-Bond Acceptors47
Rotatable Bonds28
Heavy Atoms222
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003008.17
LogP ≤ 523.55
H-Bond Donors ≤ 519
H-Bond Acceptors ≤ 1047

Analyze N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide with MolForge

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Related Compounds

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methane;trans-(1S,2S)-N-[8-amino-6-[4-methyl-6-[1-(methylamino)ethenyl]-3-pyridinyl]-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(4-methyl-5-phenylmethoxy-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(4-methyl-6-pyrazol-1-yl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-[6-methyl-5-(trifluoromethyl)-3-pyridinyl]-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide
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3-tert-butyl-1-methylpyrrole;N,N-dimethyl-5-propan-2-ylpyrimidin-2-amine;1-ethyl-4-propan-2-ylbenzene;1-ethyl-4-propan-2-ylimidazole;1-methoxy-2-propan-2-ylbenzene;1-methyl-3-propan-2-ylbenzene;1-methyl-3-propan-2-ylpyrazole;2-methyl-4-propan-2-ylpyridine;2-methyl-5-propan-2-ylpyridine;1-methyl-2-propan-2-ylpyrrole;3-propan-2-ylpyridine;N-(5-propan-2-yl-2-pyridinyl)acetamide;4-propan-2-yl-5-(trifluoromethyl)-2H-pyrrole
CID 160084574
N-[6-amino-5-[1-ethyl-3-(trifluoromethyl)pyrazol-5-yl]-2-pyridinyl]benzamide;N-[6-amino-5-[1-ethyl-3-(trifluoromethyl)pyrazol-5-yl]-2-pyridinyl]-4-methylbenzamide;N-[6-amino-5-[2-methoxy-4-(trifluoromethyl)phenyl]-2-pyridinyl]-4-methylbenzamide;N-[6-amino-5-(4-methylnaphthalen-1-yl)-2-pyridinyl]-4-methylbenzamide;N-[6-amino-5-[1-propan-2-yl-3-(trifluoromethyl)pyrazol-5-yl]-2-pyridinyl]benzamide;N-[6-amino-5-[1-propan-2-yl-3-(trifluoromethyl)pyrazol-5-yl]-2-pyridinyl]-4-methylbenzamide
CID 160230045
N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide
CID 161558931
N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide
CID 162187007
N-[4-[3-[1-[[6-(cyclopropanecarbonylamino)-4-[3-[1-[[6-(cyclopropanecarbonylamino)-3-(difluoromethyl)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-2-pyridinyl]methyl]-1,2,4-triazol-3-yl]-2-methoxyanilino]-3-(2-fluoropropan-2-yl)-2-pyridinyl]methyl]-1,2,4-triazol-3-yl]-2-methoxyanilino]-5-[fluoro(phenyl)methyl]-2-pyridinyl]cyclopropanecarboxamide
CID 166858367
2-(dimethylamino)-N-[1-[6-[4-[2-[6-fluoro-3-[4-fluoro-2-methoxy-3-[4-[1-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)pyrazol-4-yl]pyrimidin-2-yl]phenyl]-2-methoxyphenyl]pyrimidin-4-yl]pyrazol-1-yl]-2-pyridinyl]pyrrolidin-3-yl]acetamide
CID 171517309

Frequently Asked Questions

What is the IUPAC name of N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide?
The IUPAC name of N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide (CID 159872743) is N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide.
What is the SMILES notation for N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide?
The canonical SMILES for N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide is CCc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.CNC(=O)Nc1cc2cc(-c3cnn(C)c3)nc(N)c2cn1.COc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3CC3(F)F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cn1cc(-c2cc3cc(NC(=O)C4C[C@@H]4F)ncc3c(N)n2)cn1.Cn1cc(-c2cc3cc(NC(=O)[C@@H]4C[C@@H]4F)ncc3c(N)n2)cn1.Cn1cc(-c2cc3cc(NC(=O)[C@@H]4C[C@H]4F)ncc3c(N)n2)cn1.
What is the InChIKey of N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide?
The InChIKey is NSNCPJKLQQKPKO-YPDJWMGSSA-N. The full InChI is InChI=1S/C19H16F2N4O.C19H18FN5O.C19H17FN4O2.C19H17FN4O.C18H16FN5O.3C16H15FN6O.C14H15N7O/c1-10-4-2-3-5-12(10)15-6-11-7-16(23-9-13(11)17(22)24-15)25-18(26)14-8-19(14,20)21;1-2-15-11(4-3-5-22-15)16-6-10-7-17(23-9-13(10)18(21)24-16)25-19(26)12-8-14(12)20;1-26-16-5-3-2-4-11(16)15-6-10-7-17(22-9-13(10)18(21)23-15)24-19(25)12-8-14(12)20;1-10-4-2-3-5-12(10)16-6-11-7-17(22-9-14(11)18(21)23-16)24-19(25)13-8-15(13)20;1-9-11(3-2-4-21-9)15-5-10-6-16(22-8-13(10)17(20)23-15)24-18(25)12-7-14(12)19;3*1-23-7-9(5-20-23)13-2-8-3-14(19-6-11(8)15(18)21-13)22-16(24)10-4-12(10)17;1-16-14(22)20-12-4-8-3-11(9-5-18-21(2)7-9)19-13(15)10(8)6-17-12/h2-7,9,14H,8H2,1H3,(H2,22,24)(H,23,25,26);3-7,9,12,14H,2,8H2,1H3,(H2,21,24)(H,23,25,26);2-7,9,12,14H,8H2,1H3,(H2,21,23)(H,22,24,25);2-7,9,13,15H,8H2,1H3,(H2,21,23)(H,22,24,25);2-6,8,12,14H,7H2,1H3,(H2,20,23)(H,22,24,25);3*2-3,5-7,10,12H,4H2,1H3,(H2,18,21)(H,19,22,24);3-7H,1-2H3,(H2,15,19)(H2,16,17,20,22)/t;2*12-,14+;13-,15+;12-,14+;10?,12-;10-,12+;10-,12-;/m.1111011./s1.
What are the key properties of N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide?
N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide has a molecular weight of 3008.17 g/mol, XLogP of 23.55, 28 rotatable bonds, 19 hydrogen bond donors, and 47 hydrogen bond acceptors.
Where does this data come from?
All data for N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;1-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-3-methylurea;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;trans-(1S,2R)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide is sourced from PubChem (CID 159872743), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).