N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide

C107H97F7N30O7 — CID 162187007

About N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide

N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide (PubChem CID 162187007) has the molecular formula C107H97F7N30O7 and a molecular weight of 2048.14 g/mol. Its IUPAC name is N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide.

Molecular Properties

• Compound Name: N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide
• PubChem CID: 162187007
• Molecular Formula: C107H97F7N30O7
• Molecular Weight: 2048.14 g/mol
• Exact Mass: 2046.80
• IUPAC Name: N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide
• SMILES: CCc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.COc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3CC3(F)F)ncc2c(N)n1.Cc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cn1cc(-c2cc3cc(NC(=O)C4C[C@@H]4F)ncc3c(N)n2)cn1.Cn1cc(-c2cc3cc(NC(=O)[C@@H]4C[C@@H]4F)ncc3c(N)n2)cn1
• InChI: InChI=1S/C19H16F2N4O.C19H18FN5O.C19H17FN4O2.C18H16FN5O.2C16H15FN6O/c1-10-4-2-3-5-12(10)15-6-11-7-16(23-9-13(11)17(22)24-15)25-18(26)14-8-19(14,20)21;1-2-15-11(4-3-5-22-15)16-6-10-7-17(23-9-13(10)18(21)24-16)25-19(26)12-8-14(12)20;1-26-16-5-3-2-4-11(16)15-6-10-7-17(22-9-13(10)18(21)23-15)24-19(25)12-8-14(12)20;1-9-11(3-2-4-21-9)15-5-10-6-16(22-8-13(10)17(20)23-15)24-18(25)12-7-14(12)19;2*1-23-7-9(5-20-23)13-2-8-3-14(19-6-11(8)15(18)21-13)22-16(24)10-4-12(10)17/h2-7,9,14H,8H2,1H3,(H2,22,24)(H,23,25,26);3-7,9,12,14H,2,8H2,1H3,(H2,21,24)(H,23,25,26);2-7,9,12,14H,8H2,1H3,(H2,21,23)(H,22,24,25);2-6,8,12,14H,7H2,1H3,(H2,20,23)(H,22,24,25);2*2-3,5-7,10,12H,4H2,1H3,(H2,18,21)(H,19,22,24)/t;3*12-,14+;10?,12-;10-,12+/m.11101/s1
• InChIKey: ZPUBIVDQXQDDDW-BIKQYTIMSA-N
• XLogP: 16.80
• TPSA: 556.05 Ų
• H-Bond Donors: 12
• H-Bond Acceptors: 31
• Rotatable Bonds: 20
• Heavy Atoms: 151
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2048.14
LogP ≤ 5	16.80
H-Bond Donors ≤ 5	12
H-Bond Acceptors ≤ 10	31

Frequently Asked Questions

What is the IUPAC name of N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide?

The IUPAC name of N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide (CID 162187007) is N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide.

What is the SMILES notation for N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide?

The canonical SMILES for N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide is CCc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.COc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)C3CC3(F)F)ncc2c(N)n1.Cc1ncccc1-c1cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c(N)n1.Cn1cc(-c2cc3cc(NC(=O)C4C[C@@H]4F)ncc3c(N)n2)cn1.Cn1cc(-c2cc3cc(NC(=O)[C@@H]4C[C@@H]4F)ncc3c(N)n2)cn1.

What is the InChIKey of N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide?

The InChIKey is ZPUBIVDQXQDDDW-BIKQYTIMSA-N. The full InChI is InChI=1S/C19H16F2N4O.C19H18FN5O.C19H17FN4O2.C18H16FN5O.2C16H15FN6O/c1-10-4-2-3-5-12(10)15-6-11-7-16(23-9-13(11)17(22)24-15)25-18(26)14-8-19(14,20)21;1-2-15-11(4-3-5-22-15)16-6-10-7-17(23-9-13(10)18(21)24-16)25-19(26)12-8-14(12)20;1-26-16-5-3-2-4-11(16)15-6-10-7-17(22-9-13(10)18(21)23-15)24-19(25)12-8-14(12)20;1-9-11(3-2-4-21-9)15-5-10-6-16(22-8-13(10)17(20)23-15)24-18(25)12-7-14(12)19;2*1-23-7-9(5-20-23)13-2-8-3-14(19-6-11(8)15(18)21-13)22-16(24)10-4-12(10)17/h2-7,9,14H,8H2,1H3,(H2,22,24)(H,23,25,26);3-7,9,12,14H,2,8H2,1H3,(H2,21,24)(H,23,25,26);2-7,9,12,14H,8H2,1H3,(H2,21,23)(H,22,24,25);2-6,8,12,14H,7H2,1H3,(H2,20,23)(H,22,24,25);2*2-3,5-7,10,12H,4H2,1H3,(H2,18,21)(H,19,22,24)/t;3*12-,14+;10?,12-;10-,12+/m.11101/s1.

What are the key properties of N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide?

N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide has a molecular weight of 2048.14 g/mol, XLogP of 16.80, 20 rotatable bonds, 12 hydrogen bond donors, and 31 hydrogen bond acceptors.

Where does this data come from?

All data for N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2,2-difluorocyclopropane-1-carboxamide;(2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-ethyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methoxyphenyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(1-methylpyrazol-4-yl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide;cis-(1S,2S)-N-[8-amino-6-(2-methyl-3-pyridinyl)-2,7-naphthyridin-3-yl]-2-fluorocyclopropane-1-carboxamide is sourced from PubChem (CID 162187007), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).