6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide

C138H137F14N27O12S6 — CID 159882160

About 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide

6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide (PubChem CID 159882160) has the molecular formula C138H137F14N27O12S6 and a molecular weight of 2824.16 g/mol. Its IUPAC name is 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide.

Molecular Properties

• Compound Name: 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide
• PubChem CID: 159882160
• Molecular Formula: C138H137F14N27O12S6
• Molecular Weight: 2824.16 g/mol
• Exact Mass: 2821.90
• IUPAC Name: 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide
• SMILES: CC(C)n1c(-c2ccc(S(=O)(=O)N[C@@H](C)C3CC3)cn2)c(C#N)c2cc(F)ccc21.Cc1cc2c(cc1F)c(C#N)c(-c1ccc(S(=O)(=O)N[C@H](C)C(F)(F)F)cn1)n2C1CCC1.Cc1ccc2c(C#N)c(-c3ncc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn3)n(C3CCCCC3)c2c1.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)NC(C)(C)C(F)(F)F)cn1)n2C1CCCC1.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)N[C@@H](C)C3CC3)cn1)n2C1CCCCC1.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(-c2ncccn2)c2ccc(F)cc12
• InChI: InChI=1S/C26H30N4O2S.C24H25F3N4O2S.C23H24F3N5O2S.C22H20F4N4O2S.C22H23FN4O2S.C21H15F3N6O2S/c1-17-8-13-25-22(14-17)23(15-27)26(30(25)20-6-4-3-5-7-20)24-12-11-21(16-28-24)33(31,32)29-18(2)19-9-10-19;1-15-8-11-21-18(12-15)19(13-28)22(31(21)16-6-4-5-7-16)20-10-9-17(14-29-20)34(32,33)30-23(2,3)24(25,26)27;1-14-8-9-18-19(11-27)21(31(20(18)10-14)16-6-4-3-5-7-16)22-28-12-17(13-29-22)34(32,33)30-15(2)23(24,25)26;1-12-8-20-16(9-18(12)23)17(10-27)21(30(20)14-4-3-5-14)19-7-6-15(11-28-19)33(31,32)29-13(2)22(24,25)26;1-13(2)27-21-9-6-16(23)10-18(21)19(11-24)22(27)20-8-7-17(12-25-20)30(28,29)26-14(3)15-4-5-15;22-9-14(10-23)29-33(31,32)15-3-4-18(28-12-15)20-17(11-25)16-8-13(24)2-5-19(16)30(20)21-26-6-1-7-27-21/h8,11-14,16,18-20,29H,3-7,9-10H2,1-2H3;8-12,14,16,30H,4-7H2,1-3H3;8-10,12-13,15-16,30H,3-7H2,1-2H3;6-9,11,13-14,29H,3-5H2,1-2H3;6-10,12-15,26H,4-5H2,1-3H3;1-8,12,14,29H,9-10H2/t18-;;15-;13-;14-;/m0.010./s1
• InChIKey: NTQUOWAYDVYIPO-AYEZXHIVSA-N
• XLogP: 28.52
• TPSA: 565.35 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 33
• Rotatable Bonds: 34
• Heavy Atoms: 197
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2824.16
LogP ≤ 5	28.52
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	33

Frequently Asked Questions

What is the IUPAC name of 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide?

The IUPAC name of 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide (CID 159882160) is 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide.

What is the SMILES notation for 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide?

The canonical SMILES for 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide is CC(C)n1c(-c2ccc(S(=O)(=O)N[C@@H](C)C3CC3)cn2)c(C#N)c2cc(F)ccc21.Cc1cc2c(cc1F)c(C#N)c(-c1ccc(S(=O)(=O)N[C@H](C)C(F)(F)F)cn1)n2C1CCC1.Cc1ccc2c(C#N)c(-c3ncc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn3)n(C3CCCCC3)c2c1.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)NC(C)(C)C(F)(F)F)cn1)n2C1CCCC1.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)N[C@@H](C)C3CC3)cn1)n2C1CCCCC1.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(-c2ncccn2)c2ccc(F)cc12.

What is the InChIKey of 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide?

The InChIKey is NTQUOWAYDVYIPO-AYEZXHIVSA-N. The full InChI is InChI=1S/C26H30N4O2S.C24H25F3N4O2S.C23H24F3N5O2S.C22H20F4N4O2S.C22H23FN4O2S.C21H15F3N6O2S/c1-17-8-13-25-22(14-17)23(15-27)26(30(25)20-6-4-3-5-7-20)24-12-11-21(16-28-24)33(31,32)29-18(2)19-9-10-19;1-15-8-11-21-18(12-15)19(13-28)22(31(21)16-6-4-5-7-16)20-10-9-17(14-29-20)34(32,33)30-23(2,3)24(25,26)27;1-14-8-9-18-19(11-27)21(31(20(18)10-14)16-6-4-3-5-7-16)22-28-12-17(13-29-22)34(32,33)30-15(2)23(24,25)26;1-12-8-20-16(9-18(12)23)17(10-27)21(30(20)14-4-3-5-14)19-7-6-15(11-28-19)33(31,32)29-13(2)22(24,25)26;1-13(2)27-21-9-6-16(23)10-18(21)19(11-24)22(27)20-8-7-17(12-25-20)30(28,29)26-14(3)15-4-5-15;22-9-14(10-23)29-33(31,32)15-3-4-18(28-12-15)20-17(11-25)16-8-13(24)2-5-19(16)30(20)21-26-6-1-7-27-21/h8,11-14,16,18-20,29H,3-7,9-10H2,1-2H3;8-12,14,16,30H,4-7H2,1-3H3;8-10,12-13,15-16,30H,3-7H2,1-2H3;6-9,11,13-14,29H,3-5H2,1-2H3;6-10,12-15,26H,4-5H2,1-3H3;1-8,12,14,29H,9-10H2/t18-;;15-;13-;14-;/m0.010./s1.

What are the key properties of 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide?

6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide has a molecular weight of 2824.16 g/mol, XLogP of 28.52, 34 rotatable bonds, 6 hydrogen bond donors, and 33 hydrogen bond acceptors.

Where does this data come from?

All data for 6-(3-cyano-1-cyclobutyl-5-fluoro-6-methylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclohexyl-5-methylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclohexyl-6-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-propan-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(3-cyano-5-fluoro-1-pyrimidin-2-ylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide is sourced from PubChem (CID 159882160), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).