(1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide

C134H122N34O10 — CID 160524099

About (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide

(1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide (PubChem CID 160524099) has the molecular formula C134H122N34O10 and a molecular weight of 2368.68 g/mol. Its IUPAC name is (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide.

Molecular Properties

• Compound Name: (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide
• PubChem CID: 160524099
• Molecular Formula: C134H122N34O10
• Molecular Weight: 2368.68 g/mol
• Exact Mass: 2367.01
• IUPAC Name: (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide
• SMILES: C=C1Nc2cc(C)c(-c3cc4cc(NC(=O)[C@@H]5C[C@H]5C#N)ncc4c(N)n3)cc2C1O.C=C1Nc2cc(C)c(-c3cc4cc(NC(=O)[C@H]5C[C@@H]5C#N)ncc4c(N)n3)cc2C1O.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3[C@H]4CNC(=O)[C@H]43)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3[C@@H]4CNC(=O)[C@@H]43)ncc2c(N)n1
• InChI: InChI=1S/2C23H20N6O2.2C23H22N6O.2C21H19N5O2/c2*1-10-3-18-16(21(30)11(2)27-18)7-14(10)19-5-12-6-20(26-9-17(12)22(25)28-19)29-23(31)15-4-13(15)8-24;2*1-13-5-3-4-6-16(13)20-7-14-8-21(25-11-19(14)22(24)27-20)28-23(30)18-9-17(18)15-10-26-29(2)12-15;2*1-10-4-2-3-5-12(10)15-6-11-7-16(23-8-13(11)19(22)25-15)26-21(28)18-14-9-24-20(27)17(14)18/h2*3,5-7,9,13,15,21,27,30H,2,4H2,1H3,(H2,25,28)(H,26,29,31);2*3-8,10-12,17-18H,9H2,1-2H3,(H2,24,27)(H,25,28,30);2*2-8,14,17-18H,9H2,1H3,(H2,22,25)(H,24,27)(H,23,26,28)/t2*13-,15+,21?;2*17-,18+;2*14-,17+,18+/m101010/s1
• InChIKey: QUQZEVGCZJGEKP-WFPRNFKESA-N
• XLogP: 18.08
• TPSA: 691.34 Ų
• H-Bond Donors: 18
• H-Bond Acceptors: 36
• Rotatable Bonds: 20
• Heavy Atoms: 178
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2368.68
LogP ≤ 5	18.08
H-Bond Donors ≤ 5	18
H-Bond Acceptors ≤ 10	36

Frequently Asked Questions

What is the IUPAC name of (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide?

The IUPAC name of (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide (CID 160524099) is (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide.

What is the SMILES notation for (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide?

The canonical SMILES for (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide is C=C1Nc2cc(C)c(-c3cc4cc(NC(=O)[C@@H]5C[C@H]5C#N)ncc4c(N)n3)cc2C1O.C=C1Nc2cc(C)c(-c3cc4cc(NC(=O)[C@H]5C[C@@H]5C#N)ncc4c(N)n3)cc2C1O.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3C[C@H]3c3cnn(C)c3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@@H]3[C@H]4CNC(=O)[C@H]43)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3C[C@@H]3c3cnn(C)c3)ncc2c(N)n1.Cc1ccccc1-c1cc2cc(NC(=O)[C@H]3[C@@H]4CNC(=O)[C@@H]43)ncc2c(N)n1.

What is the InChIKey of (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide?

The InChIKey is QUQZEVGCZJGEKP-WFPRNFKESA-N. The full InChI is InChI=1S/2C23H20N6O2.2C23H22N6O.2C21H19N5O2/c2*1-10-3-18-16(21(30)11(2)27-18)7-14(10)19-5-12-6-20(26-9-17(12)22(25)28-19)29-23(31)15-4-13(15)8-24;2*1-13-5-3-4-6-16(13)20-7-14-8-21(25-11-19(14)22(24)27-20)28-23(30)18-9-17(18)15-10-26-29(2)12-15;2*1-10-4-2-3-5-12(10)15-6-11-7-16(23-8-13(11)19(22)25-15)26-21(28)18-14-9-24-20(27)17(14)18/h2*3,5-7,9,13,15,21,27,30H,2,4H2,1H3,(H2,25,28)(H,26,29,31);2*3-8,10-12,17-18H,9H2,1-2H3,(H2,24,27)(H,25,28,30);2*2-8,14,17-18H,9H2,1H3,(H2,22,25)(H,24,27)(H,23,26,28)/t2*13-,15+,21?;2*17-,18+;2*14-,17+,18+/m101010/s1.

What are the key properties of (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide?

(1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide has a molecular weight of 2368.68 g/mol, XLogP of 18.08, 20 rotatable bonds, 18 hydrogen bond donors, and 36 hydrogen bond acceptors.

Where does this data come from?

All data for (1R,5S,6R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;(1S,5R,6S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-oxo-3-azabicyclo[3.1.0]hexane-6-carboxamide;cis-(1S,2S)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;cis-(1R,2R)-N-[8-amino-6-(3-hydroxy-6-methyl-2-methylidene-1,3-dihydroindol-5-yl)-2,7-naphthyridin-3-yl]-2-cyanocyclopropane-1-carboxamide;trans-(1S,2S)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide;trans-(1R,2R)-N-[8-amino-6-(2-methylphenyl)-2,7-naphthyridin-3-yl]-2-(1-methylpyrazol-4-yl)cyclopropane-1-carboxamide is sourced from PubChem (CID 160524099), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).