6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide

C130H121ClF21N27O12S6 — CID 160708742

About 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide

6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide (PubChem CID 160708742) has the molecular formula C130H121ClF21N27O12S6 and a molecular weight of 2880.39 g/mol. Its IUPAC name is 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide.

Molecular Properties

• Compound Name: 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide
• PubChem CID: 160708742
• Molecular Formula: C130H121ClF21N27O12S6
• Molecular Weight: 2880.39 g/mol
• Exact Mass: 2877.74
• IUPAC Name: 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide
• SMILES: CCc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCCC1.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(Cl)ccc3n2C2CCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1cnc(-c2c(C#N)c3cc(C(F)F)ccc3n2C2CCC2)nc1)C(F)(F)F.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2ccc(C(F)F)cc12.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2ccc(C(F)F)cc12.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2ccc(CF)cc12
• InChI: InChI=1S/C24H26F2N4O2S.C22H20F4N4O2S.C21H18ClF3N4O2S.C21H18F5N5O2S.C21H19F4N5O2S.C21H20F3N5O2S/c1-2-16-7-10-23-20(11-16)21(14-27)24(30(23)18-5-3-4-6-18)22-9-8-19(15-28-22)33(31,32)29-17(12-25)13-26;23-9-14(10-24)29-33(31,32)16-5-6-19(28-12-16)21-18(11-27)17-8-13(22(25)26)4-7-20(17)30(21)15-2-1-3-15;1-12(21(23,24)25)28-32(30,31)15-6-7-18(27-11-15)20-17(10-26)16-9-13(22)5-8-19(16)29(20)14-3-2-4-14;1-11(21(24,25)26)30-34(32,33)14-9-28-20(29-10-14)18-16(8-27)15-7-12(19(22)23)5-6-17(15)31(18)13-3-2-4-13;22-7-13(8-23)29-33(31,32)15-10-27-21(28-11-15)19-17(9-26)16-6-12(20(24)25)4-5-18(16)30(19)14-2-1-3-14;22-7-13-4-5-19-17(6-13)18(10-25)20(29(19)15-2-1-3-15)21-26-11-16(12-27-21)32(30,31)28-14(8-23)9-24/h7-11,15,17-18,29H,2-6,12-13H2,1H3;4-8,12,14-15,22,29H,1-3,9-10H2;5-9,11-12,14,28H,2-4H2,1H3;5-7,9-11,13,19,30H,2-4H2,1H3;4-6,10-11,13-14,20,29H,1-3,7-8H2;4-6,11-12,14-15,28H,1-3,7-9H2/t;;12-;11-;;/m..00../s1
• InChIKey: RROMZIAVXJPAAW-OPLSRYOPSA-N
• XLogP: 27.67
• TPSA: 565.35 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 33
• Rotatable Bonds: 43
• Heavy Atoms: 197
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2880.39
LogP ≤ 5	27.67
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	33

Frequently Asked Questions

What is the IUPAC name of 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide?

The IUPAC name of 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide (CID 160708742) is 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide.

What is the SMILES notation for 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide?

The canonical SMILES for 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide is CCc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)NC(CF)CF)cn1)n2C1CCCC1.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(Cl)ccc3n2C2CCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1cnc(-c2c(C#N)c3cc(C(F)F)ccc3n2C2CCC2)nc1)C(F)(F)F.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2ccc(C(F)F)cc12.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2ccc(C(F)F)cc12.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2ccc(CF)cc12.

What is the InChIKey of 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide?

The InChIKey is RROMZIAVXJPAAW-OPLSRYOPSA-N. The full InChI is InChI=1S/C24H26F2N4O2S.C22H20F4N4O2S.C21H18ClF3N4O2S.C21H18F5N5O2S.C21H19F4N5O2S.C21H20F3N5O2S/c1-2-16-7-10-23-20(11-16)21(14-27)24(30(23)18-5-3-4-6-18)22-9-8-19(15-28-22)33(31,32)29-17(12-25)13-26;23-9-14(10-24)29-33(31,32)16-5-6-19(28-12-16)21-18(11-27)17-8-13(22(25)26)4-7-20(17)30(21)15-2-1-3-15;1-12(21(23,24)25)28-32(30,31)15-6-7-18(27-11-15)20-17(10-26)16-9-13(22)5-8-19(16)29(20)14-3-2-4-14;1-11(21(24,25)26)30-34(32,33)14-9-28-20(29-10-14)18-16(8-27)15-7-12(19(22)23)5-6-17(15)31(18)13-3-2-4-13;22-7-13(8-23)29-33(31,32)15-10-27-21(28-11-15)19-17(9-26)16-6-12(20(24)25)4-5-18(16)30(19)14-2-1-3-14;22-7-13-4-5-19-17(6-13)18(10-25)20(29(19)15-2-1-3-15)21-26-11-16(12-27-21)32(30,31)28-14(8-23)9-24/h7-11,15,17-18,29H,2-6,12-13H2,1H3;4-8,12,14-15,22,29H,1-3,9-10H2;5-9,11-12,14,28H,2-4H2,1H3;5-7,9-11,13,19,30H,2-4H2,1H3;4-6,10-11,13-14,20,29H,1-3,7-8H2;4-6,11-12,14-15,28H,1-3,7-9H2/t;;12-;11-;;/m..00../s1.

What are the key properties of 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide?

6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide has a molecular weight of 2880.39 g/mol, XLogP of 27.67, 43 rotatable bonds, 6 hydrogen bond donors, and 33 hydrogen bond acceptors.

Where does this data come from?

All data for 6-(5-chloro-3-cyano-1-cyclobutylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(difluoromethyl)indol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-5-(fluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclopentyl-5-ethylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide is sourced from PubChem (CID 160708742), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).