6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide

C132H119F21N26O12S6 — CID 161270172

About 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide

6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide (PubChem CID 161270172) has the molecular formula C132H119F21N26O12S6 and a molecular weight of 2852.93 g/mol. Its IUPAC name is 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide.

Molecular Properties

• Compound Name: 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide
• PubChem CID: 161270172
• Molecular Formula: C132H119F21N26O12S6
• Molecular Weight: 2852.93 g/mol
• Exact Mass: 2850.75
• IUPAC Name: 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide
• SMILES: CC(C)NS(=O)(=O)c1cnc(-c2c(C#N)c3ccc(C(F)F)cc3n2C2CCC2)nc1.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)NC3(C(F)(F)F)CC3)cn1)n2C1CCC1.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2cc(C(F)F)ccc12.N#Cc1c(-c2ccc(S(=O)(=O)NC3(C(F)(F)F)CC3)cn2)n(C2CCC2)c2ccc(F)cc12.N#Cc1c(-c2ccc(S(=O)(=O)NC3(C(F)(F)F)CC3)cn2)n(C2CCCC2)c2ccc(F)cc12.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2cc(C(F)F)ccc12
• InChI: InChI=1S/C23H20F4N4O2S.C23H21F3N4O2S.C22H18F4N4O2S.C22H20F4N4O2S.C21H19F4N5O2S.C21H21F2N5O2S/c24-14-5-8-20-17(11-14)18(12-28)21(31(20)15-3-1-2-4-15)19-7-6-16(13-29-19)34(32,33)30-22(9-10-22)23(25,26)27;1-14-5-8-20-17(11-14)18(12-27)21(30(20)15-3-2-4-15)19-7-6-16(13-28-19)33(31,32)29-22(9-10-22)23(24,25)26;23-13-4-7-19-16(10-13)17(11-27)20(30(19)14-2-1-3-14)18-6-5-15(12-28-18)33(31,32)29-21(8-9-21)22(24,25)26;23-9-14(10-24)29-33(31,32)16-5-7-19(28-12-16)21-18(11-27)17-6-4-13(22(25)26)8-20(17)30(21)15-2-1-3-15;22-7-13(8-23)29-33(31,32)15-10-27-21(28-11-15)19-17(9-26)16-5-4-12(20(24)25)6-18(16)30(19)14-2-1-3-14;1-12(2)27-31(29,30)15-10-25-21(26-11-15)19-17(9-24)16-7-6-13(20(22)23)8-18(16)28(19)14-4-3-5-14/h5-8,11,13,15,30H,1-4,9-10H2;5-8,11,13,15,29H,2-4,9-10H2,1H3;4-7,10,12,14,29H,1-3,8-9H2;4-8,12,14-15,22,29H,1-3,9-10H2;4-6,10-11,13-14,20,29H,1-3,7-8H2;6-8,10-12,14,20,27H,3-5H2,1-2H3
• InChIKey: VDRZVXKUYPJAIU-UHFFFAOYSA-N
• XLogP: 28.36
• TPSA: 552.46 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 32
• Rotatable Bonds: 37
• Heavy Atoms: 197
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2852.93
LogP ≤ 5	28.36
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	32

Frequently Asked Questions

What is the IUPAC name of 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide?

The IUPAC name of 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide (CID 161270172) is 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide.

What is the SMILES notation for 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide?

The canonical SMILES for 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide is CC(C)NS(=O)(=O)c1cnc(-c2c(C#N)c3ccc(C(F)F)cc3n2C2CCC2)nc1.Cc1ccc2c(c1)c(C#N)c(-c1ccc(S(=O)(=O)NC3(C(F)(F)F)CC3)cn1)n2C1CCC1.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2cc(C(F)F)ccc12.N#Cc1c(-c2ccc(S(=O)(=O)NC3(C(F)(F)F)CC3)cn2)n(C2CCC2)c2ccc(F)cc12.N#Cc1c(-c2ccc(S(=O)(=O)NC3(C(F)(F)F)CC3)cn2)n(C2CCCC2)c2ccc(F)cc12.N#Cc1c(-c2ncc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCC2)c2cc(C(F)F)ccc12.

What is the InChIKey of 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide?

The InChIKey is VDRZVXKUYPJAIU-UHFFFAOYSA-N. The full InChI is InChI=1S/C23H20F4N4O2S.C23H21F3N4O2S.C22H18F4N4O2S.C22H20F4N4O2S.C21H19F4N5O2S.C21H21F2N5O2S/c24-14-5-8-20-17(11-14)18(12-28)21(31(20)15-3-1-2-4-15)19-7-6-16(13-29-19)34(32,33)30-22(9-10-22)23(25,26)27;1-14-5-8-20-17(11-14)18(12-27)21(30(20)15-3-2-4-15)19-7-6-16(13-28-19)33(31,32)29-22(9-10-22)23(24,25)26;23-13-4-7-19-16(10-13)17(11-27)20(30(19)14-2-1-3-14)18-6-5-15(12-28-18)33(31,32)29-21(8-9-21)22(24,25)26;23-9-14(10-24)29-33(31,32)16-5-7-19(28-12-16)21-18(11-27)17-6-4-13(22(25)26)8-20(17)30(21)15-2-1-3-15;22-7-13(8-23)29-33(31,32)15-10-27-21(28-11-15)19-17(9-26)16-5-4-12(20(24)25)6-18(16)30(19)14-2-1-3-14;1-12(2)27-31(29,30)15-10-25-21(26-11-15)19-17(9-24)16-7-6-13(20(22)23)8-18(16)28(19)14-4-3-5-14/h5-8,11,13,15,30H,1-4,9-10H2;5-8,11,13,15,29H,2-4,9-10H2,1H3;4-7,10,12,14,29H,1-3,8-9H2;4-8,12,14-15,22,29H,1-3,9-10H2;4-6,10-11,13-14,20,29H,1-3,7-8H2;6-8,10-12,14,20,27H,3-5H2,1-2H3.

What are the key properties of 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide?

6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide has a molecular weight of 2852.93 g/mol, XLogP of 28.36, 37 rotatable bonds, 6 hydrogen bond donors, and 32 hydrogen bond acceptors.

Where does this data come from?

All data for 6-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-(1,3-difluoropropan-2-yl)pyrimidine-5-sulfonamide;2-[3-cyano-1-cyclobutyl-6-(difluoromethyl)indol-2-yl]-N-propan-2-ylpyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-5-methylindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoroindol-2-yl)-N-[1-(trifluoromethyl)cyclopropyl]pyridine-3-sulfonamide is sourced from PubChem (CID 161270172), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).